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Merck
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主要文書

安全性情報

SRP6333

Sigma-Aldrich

CD74 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

別名:

DHLAG, HLA class II histocompatibility antigen gamma chain isoform b, HLADG, Ia-GAMMA

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About This Item

UNSPSCコード:
12352200
NACRES:
NA.32

由来生物

human

リコンビナント

expressed in E. coli

アッセイ

≥90% (SDS-PAGE)

フォーム

liquid

分子量

20.6 kDa (183 aa, 73-232 aa + His tag)

包装

pkg of 100 μg

濃度

0.5 mg/mL

不純物

<1 EU/μg endotoxin (LAL test)

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−70°C

遺伝子情報

human ... CD74(972)

詳細

HLA class II histocompatibility antigen gamma chain isoform b, also known as CD74, is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. It is upregulated in several cancers and is also expressed by nonimmune cells during inflammation. Recombinant human CD74 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

物理的形状

0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl, 1 mM DTT and 30% glycerol.

ピクトグラム

Exclamation mark

シグナルワード

Warning

危険有害性情報

危険有害性の分類

Eye Irrit. 2

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

SRP6333-100UG:


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試験成績書(COA)

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文書ライブラリにアクセスする

V Kurvari et al.
The Journal of cell biology, 143(7), 1971-1980 (1998-12-29)
During fertilization in Chlamydomonas, gametes of opposite mating types interact with each other through sex-specific adhesion molecules on their flagellar surfaces. Flagellar adhesion brings the cell bodies of the gametes into close contact and initiates a signal transduction pathway in
Ma Isabel Salazar et al.
BMC microbiology, 7, 9-9 (2007-02-01)
To be transmitted by its mosquito vector, dengue virus (DENV) must infect midgut epithelial cells, replicate and disseminate into the hemocoel, and finally infect the salivary glands, which is essential for transmission. The extrinsic incubation period (EIP) is very relevant
Keiji Tanese et al.
The Journal of investigative dermatology, 135(11), 2775-2784 (2015-06-04)
Melanoma is believed to be a highly immunogenic tumor and recent developments in immunotherapies are promising. IFN-γ produced by immune cells has a crucial role in tumor immune surveillance; however, it has also been reported to be pro-tumorigenic. In the
Stefanie Ronzheimer et al.
Frontiers in microbiology, 9, 2536-2536 (2018-11-09)
Accumulation of compatible solutes is a common stress response of microorganisms challenged by high osmolarity; it can be achieved either through synthesis or import. These processes have been intensively studied in Bacillus subtilis, where systems for the production of the
Lin Leng et al.
The Journal of experimental medicine, 197(11), 1467-1476 (2003-06-05)
Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to have been described, and it has emerged recently to be an important regulator of innate and adaptive immunity. MIF is an upstream activator of monocytes/macrophages, and

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