SRP3285

GREMLIN-1 human

recombinant, expressed in CHO cells, ≥90% (SDS-PAGE), ≥90% (HPLC)

• 別名: CKTSF1B1, DAND2, DRM
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in CHO cells
• アッセイ: ≥90% (HPLC); ≥90% (SDS-PAGE)
• 形状: lyophilized
• 有効性: 0.07-0.11 μg/mL
• 分子量: 13.7 kDa
• 包装: pkg of 50 μg
• 不純物: <0.1 EU/μg endotoxin, tested
• 色: white to off-white
• UniProtアクセッション番号: O60565
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... GREM1(26585)

詳細

詳細

Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the transforming growth factor-β (TGF-β) family and regulate their activity by inhibiting their access to signaling receptors. The gene encoding this protein is localized on human chromosome 15q13.3. Recombinant Gremlin-1 is a 13.7kDa protein containing 160 amino acid residues.

生物化学的／生理学的作用

The interplay between transforming growth factor-β (TGF-β) ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of bone morphogenetic proteins -2,-4,-7 (BMP-2, -4, and -7). The protein has a role in limb and digit formation and in nephrogenesis. It also plays a role in carcinogenesis and kidney branching morphogenesis.

物理的形状

Lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 150 mM NaCl.

再構成

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable