SML3997

FOY-251 mesylate

≥98% (HPLC)

• 別名: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic acid, methanesulfonate; 4-(4-Guanidinobenzoyloxy)phenylacetic acid, methanesulfonate, CC6 mesylate salt, Camostat active metabolite, FOY 251 mesylate salt, FOY 305 active metabolite, FOY-305 active metabolite, FOY251 mesylate salt, GBPA mesylate salt
• 実験式（ヒル表記法）: C₁₆H₁₅N₃O₄·CH₄O₃S
• CAS番号: 71079-09-9
• 分子量: 409.41
• MDL番号: MFCD09842546
• UNSPSCコード: 51111800
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(CC(O)=O)C=C2.O=S(O)(C)=O

詳細

生物化学的／生理学的作用

Trypsin-like serine protease inhibitor Camostat (FOY-305) active metabolite with inhibitory potency against transmembrane serine protease 2 (TMPRSS2).



FOY-251 is a trypsin-like serine protease inhibitor and an active metabolite of the oral drug Camostat/FOY-305 (trypsin IC50 = 51/55 nM by FOY-305/FOY-251; plasma kallikrein/plasmin IC50 = 1.48/2.64 μM by FOY-305 and 2.32/12.5 μM by FOY-251). FOY-251 and FOY-305 are also potent inhibitor against transmembrane serine protease 2 (TMPRSS2 IC50 = 6.2/33.3 nM by by FOY-305/FOY-251) that primes SARS-CoV-2 spike protein for host cell entry.

注意

Hygroscopic

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H315
• 注意書き: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• 危険有害性の分類: Acute Tox. 4 Oral - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable