SML3457

JX06

≥98% (HPLC)

• 別名: 4,4′-(Dithiodicarbonothioyl)bis[morpholine], 4-Morpholinethiocarbonyl disulfide, Bis(4-morpholinethiocarbonyl) disulfide, Bis(oxydi-2,1-ethanediyl)-thiuram disulfide, Dimorpholinethiuram disulfide, JX 06, JX-06, NSC 402538
• 実験式（ヒル表記法）: C₁₀H₁₆N₂O₂S₄
• CAS番号: 729-46-4
• 分子量: 324.51
• MDL番号: MFCD00072237
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: -10 to -25°C
• InChI: 1S/C10H16N2O2S4/c15-9(11-1-5-13-6-2-11)17-18-10(16)12-3-7-14-8-4-12/h1-8H2
• InChI Key: KKVYOWPPMNSLCP-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

JX06 is a potent, PDK1-selective, covalent pyruvate dehydrogenase (PDH) kinase (PDHK, PDK) inhibitor (PDK1/2/3 IC50 = 49/101/313 nM; PDK4 IC50 >10 µM, IC50 >10 µM against >300 other kinases). JX06 inhibits cellular PDK substrate PDHA1 Ser293/232 phosphorylation, resulting in reduced aerobic glycolysis and cancer proliferation in cultures (1-10 µM) and in mice in vivo (40-80 mg/kg via daily i.p. injection; A549 & HT-29 xenografts). JX06 is shown to target PDK1 Cys240 for covalent modification.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable