SML2314

Celgosivir

≥98% (HPLC)

• 別名: 6-O-Butanoylcastanospermine, 6-O-Butyrylcastanospermine, BuCast, Butanoic acid (1S,6S,7S,8R,8aR)-octahydro-1,7,8-trihydroxy-6-indolizinyl ester, Butanoic acid [1S-(1α,6β,7α,8β,8aβ)]-octahydro-1,7,8-trihydroxy-6-indolizinyl ester, MDL 28,574, MDL 28574, MDL-28574
• 実験式（ヒル表記法）: C₁₂H₂₁NO₅
• CAS番号: 121104-96-9
• 分子量: 259.30
• MDL番号: MFCD00886617
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated; under inert gas
• 色: white to beige
• 溶解性: H₂O: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: O[C@@H]1[C@@H](OC(CCC)=O)CN2[C@@]([C@@H](O)CC2)([H])[C@H]1O
• InChI: 1S/C12H21NO5/c1-2-3-9(15)18-8-6-13-5-4-7(14)10(13)12(17)11(8)16/h7-8,10-12,14,16-17H,2-6H2,1H3/t7-,8-,10+,11+,12+/m0/s1
• InChI Key: HTJGLYIJVSDQAE-VWNXEWBOSA-N

詳細

生物化学的／生理学的作用

Celgosivir is a prodrug of natural bicyclic iminosugar castanospermine that exhibits antiviral activity in vivo including HCV and dengue. Celgosivir is an inhibitor of α-glucosidases, which inhibits glycoprotein processing in cell culture. Apparently inhibition of α-glucosidases within infected cell prevents secretion of virus.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable