おすすめの製品
品質水準
アッセイ
≥98% (HPLC)
形状
powder
色
white to beige
溶解性
DMSO: 20 mg/mL, clear
保管温度
2-8°C
SMILES記法
C[C@@]12C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@]4(O[C@@](C6CCCCC6)([H])O5)C(COC(C(C)C)=O)=O)=CC(C=C1)=O
InChI
1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1
InChI Key
LUKZNWIVRBCLON-GXOBDPJESA-N
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関連するカテゴリー
生物化学的／生理学的作用
Ciclesonide is a glucocorticoid antiasthmatic prodrug. It is de-esterified in the lung to the active metabolite.
Ciclesonide is a glucocorticoid antiasthmatic prodrug; it is de-esterified in the lung to the active metabolite.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Michael Stoeck et al.
The Journal of pharmacology and experimental therapeutics, 309(1), 249-258 (2004-01-14)
The glucocorticoid ciclesonide is the 2'R-epimer of 2'-cyclohexyl-11beta-hydroxy-21-isobutyryloxy-16bH-dioxolo[5',4':16,17]pregna-1,4-diene-3,20-dione. The active metabolite desisobutyryl-ciclesonide (des-CIC) is derived from ciclesonide by esterase cleavage of isobutyrate at the C21 position. The relative binding affinities at the rat glucocorticoid receptor were dexamethasone, 100; ciclesonide, 12;
Jatinder Kaur Mukker et al.
Journal of pharmaceutical sciences, 105(9), 2509-2514 (2016-06-25)
Inhaled corticosteroids are used as one of the first-line drug therapy in patients with asthma. However, their long-term use is associated with various oropharyngeal and systemic side and adverse effects. Design of pro-soft drug is one of the strategies, which
Brian S Liddell et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 54(1), 99-104 (2016-06-11)
This case series intends to highlight the association between decreased linear growth velocity and adrenal suppression in patients receiving inhaled corticosteroids for asthma. A potential treatment option is also discussed. Adrenal suppression secondary to inhaled corticosteroids has previously been reported
D S Postma et al.
The European respiratory journal, 17(6), 1083-1088 (2001-08-09)
The study addressed the question whether the novel inhaled prodrug corticosteroid ciclesonide is equally effective when inhaled in the morning compared to the evening. For this purpose a double-blind, randomized, parallel group study was initiated in which 209 asthmatic patients
Wheezing in older children asthma
Respiratory medicine case reports, 686-721 (2019)
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