SML1136

SW155246

≥98% (HPLC)

• 別名: 4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
• 実験式（ヒル表記法）: C₁₆H₁₁ClN₂O₅S
• CAS番号: 420092-79-1
• 分子量: 378.79
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825672
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: protect from light
• 色: white to light brown
• 溶解性: DMSO: 10 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: OC1=CC=C(NS(=O)(C2=CC=C(Cl)C([N+]([O-])=O)=C2)=O)C3=C1C=CC=C3
• InChI: 1S/C16H11ClN2O5S/c17-13-6-5-10(9-15(13)19(21)22)25(23,24)18-14-7-8-16(20)12-4-2-1-3-11(12)14/h1-9,18,20H
• InChI Key: JDYDEJYIVZNWQU-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor that demethylates cytosines in vivo in a cell-based assay without affecting protein levels or generating reactive oxygen species. SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.

SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor.

特徴および利点

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その他情報

light sensitive

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable