おすすめの製品
結合体
peroxidase conjugate
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
詳細
Research area: Microbiome
フォーム
lyophilized powder
分子量
~33 kDa
交差性
Staphylococcus aureus (alpha-Toxin (a-Hemolysin) )
濃度
~4 mg/mL
テクニック
direct ELISA: 1:2,000-1:4,000 using 1 μg/mL Staphylococcal alpha-Toxin (a-Hemolysin) for coating.
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
Staphylococcus aureus subsp. aureus NCTC 8325 ... SAOUHSC_01121(3920722)
詳細
Staphylococcal alpha-Toxin is a pore forming cytotoxin. Native alpha toxin is a water-soluble monomer but later on gets converted to β-barrel in the host membranes. It is 34 kDa protein. The N- terminal and the C-terminal are involved in forming a membrane-binding epitope and the central domain forms a membrane-inserting, pore forming domain.
特異性
Anti-Staphylococcal alpha-Toxin-peroxidase antibody specifically recognizes Staphylococcal alpha-Toxin (?-Hemolysin) and has no cross reactivity with Staphylococcal Enterotoxin A (SEA), Cholera Toxin or Pseudomonas Exotoxin A
免疫原
purified toxin from Staphylococcus aureus
アプリケーション
The antibody may be used in various immunochemical techniques including ELISA
生物化学的/生理学的作用
Staphylococcal alpha-Toxin plays a role in binding to the host membrane. At higher concentrations it makes the cells which are devoid of receptors to become more permeable and hence also to protein-free lipid bilayers.
診断上の意義
Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
物理的形状
Supplied as a lyophilized powder.
保管および安定性
Store the lyophilized product at 2–8 °C. For extended storage after reconstitution, keep at –20 °C in working aliquots. Avoid repeated freeze-thaw cycles. For continuous use after reconstitution, keep at 2–8 °C for up to 1 month. Solutions at working dilution should be discarded if not used within 12 hours.
免責事項
For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.


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保管分類コード
11 - Combustible Solids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
毒物及び劇物取締法
劇物
Jan Code
SAB4200827-1VL:
SAB4200827-BULK:
SAB4200827-VAR:
最新バージョンのいずれかを選択してください:
Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: prototypes of pore-forming bacterial cytolysins
Bhakdi S, et al.
Archives of Microbiology, 165(2), 73-79 (1996)
Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury
Wilke GA and Wardenburg JB
Proceedings of the National Academy of Sciences of the USA, 107(30), 13473-13478 (2010)
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