SAB4200124

Anti-Nexilin antibody,Mouse monoclonal

clone NX-38, purified from hybridoma cell culture

• 別名: 抗NEXN抗体
• UNSPSCコード: 12352203
• NACRES: NA.43

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: purified from hybridoma cell culture
• 抗体製品タイプ: primary antibodies
• クローン: NX-38, monoclonal
• 形状: buffered aqueous solution
• 分子量: antigen 80 kDa
• 化学種の反応性: mouse, human, rat
• 包装: antibody small pack of 25 μL
• 濃度: ~1 mg/mL
• テクニック: immunocytochemistry: suitable; western blot: 1-2 μg/mL using using rat brain S1 fraction extracts
• アイソタイプ: IgG2a
• UniProtアクセッション番号: Q0ZGT2
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... NEXN(91624) ; mouse ... Nexn(68810) ; rat ... Nexn(246172)

詳細

詳細

Monoclonal Anti-Nexilin (mouse IgG2a isotype) is derived from the hybridoma NX-38 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide conjugated to KLH. Nexilin is a filamentous actin-binding protein that localizes to focal contacts. Alternative splicing of the gene yields two different isoforms namely, b-nexilin and s-nexilin.

NEXN (nexilin), a cardiac Z-disc protein is made of 675 amino acids. It is present in the heart and skeletal muscle. NEXN is mapped to human chromosome 1p31.

特異性

Monoclonal Anti-Nexilin recognizes human, rat, and mouse nexilin.

アプリケーション

Anti-Nexilin antibody,Mouse monoclonal may be used in immunoblotting and immunocytochemistry.

生物化学的／生理学的作用

NEXN (nexilin) plays an important role in protecting cardiac Z-discs from forces generated within the sarcomere. Mutations in NEXN results in hypertrophic cardiomyopathy.

Nexilin may be involved in cell adhesion and migration.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

保管および安定性

Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable