SAB1300127

Anti-PACSIN2 (C-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 別名: Anti-Protein kinase C and casein kinase substrate in neurons protein 2
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 化学種の反応性: mouse, human
• テクニック: immunohistochemistry: 1:50-1:100; indirect ELISA: 1:1000; indirect immunofluorescence: 1:10-1:50; western blot: 1:100-1:500
• NCBIアクセッション番号: NP_009160
• UniProtアクセッション番号: Q9UNF0
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PACSIN2(11252)

詳細

詳細

Protein kinase C and casein kinase substrate in neurons 2 (PACSIN2), also termed syndapin II exhibits a vesicle-like cytoplasmic distribution and is ubiquitously expressed. PACSIN is phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). The protein contains EFC/F-BAR (Fes/CIP4 homology - Bin/amphiphysin/Rvs ) domain (1 FCH domain) and 1 SH3 (Src homology 3) domain. In human chromosome, the gene PACSIN2 is localized on 22q13.2.

免疫原

PACSIN2 (NP_009160, 347-381)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PACSIN2.

アプリケーション

Anti-PACSIN2 (C-term) antibody produced in rabbit has been used in immunostaining.

生物化学的／生理学的作用

Protein kinase C and casein kinase substrate in neurons 2 (PACSIN2) may play a role in vesicle formation and transport and organization of cytoskeleton. This protein homo- and hetero-aggregates with other PACSINs and thus acts as membrane associated adapter protein. It also binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP). Pacsin2 is crucial for the formation and maintenance of kidney associated tubules. Pacsin2 is involved with caveolae biogenesis in plasma membrane. Pacsin2 regulates cell migration and spreading by binding with Rac1 (Ras-related C3 botulinum toxin substrate 1) protein. Pacsin2 is involved in microspike formation and tubulation like filopodia, lamellopodia in the cell.

物理的形状

精製済みポリクローナル抗体のPBS溶液（0.09％（W/V）アジ化ナトリウム含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable