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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen ~54 kDa (synapsin IIb)
antigen ~74 kDa (synapsin IIa)
化学種の反応性
mouse, human, rat
強化検証
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1 mg/mL
テクニック
western blot: 0.5-1 μg/mL using extracts of HEK-293T cells expressing recombinant human synapsin II, mouse brain extract (S1 fraction), and rat PC12 cell lysate
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... SYN2(6854)
mouse ... Syn2(20965)
rat ... Syn2(29179)
詳細
Synapsin II (SYN-2) is a neuronal phosphoprotein present in synaptic vesicles. The SYN-2 gene is mapped to human chromosome 3p25.2. Structurally, synapsin types have a conserved N -terminal region and vary in their C-terminal region.
特異性
Anti-Synapsin II specifically recognizes human, rat, and mouse synapsin IIa and Iib.
免疫原
synthetic peptide corresponding to amino acids 438-453 located near the C-terminus of rat synapsin II, conjugated to KLH. This sequence is identical in rat synapsin IIa and IIb isoforms and mouse synapsin II, and is highly conserved in human synapsin IIa and IIb (one amino acid substitution).
アプリケーション
Anti-Synapsin II antibody produced in rabbit may be used in immunoblotting.
生物化学的／生理学的作用
Synapsins regulate synaptic vesicle clustering, neurotransmitter release, and the formation of synaptic terminals. Synapsin II is involved in the formation of synaptic terminals during neuronal development. Similar to synapsin I, synapsin II can link synaptic vesicles to the actin cytoskeleton, thus regulating the availability of synaptic vesicles for exocytosis. Synapsin II association with synaptic vesicles is controlled by phosphorylation. Synapsin II is proposed as a candidate associated with increased vulnerability to schizophrenia. It is also implicated in synaptogenesis and neurotransmitter release impairment in multiple neuropsychiatric diseases.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
保管および安定性
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
S2822-BULK:
S2822-VAR:
S2822-200UL:
S2822-100UL:
S2822-25UL:
IXO14186:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
A Ferreira et al.
Molecular medicine (Cambridge, Mass.), 4(1), 22-28 (1998-03-26)
The synapsins are a family of neuron-specific proteins, associated with the cytoplasmic surface of synaptic vesicles, which have been shown to regulate neurotransmitter release in mature synapses and to accelerate development of the nervous system. Using neuronal cultures from mice
Qi Chen et al.
American journal of human genetics, 75(5), 873-877 (2004-09-28)
Synapsin II has been proposed as a candidate gene for vulnerability to schizophrenia on the basis of its function and its location in a region of the genome implicated by linkage studies in families with schizophrenia. We recently reported positive
Seong-Yeon Bae et al.
Experimental neurobiology, 26(2), 82-89 (2017-04-27)
Translationally controlled tumor protein (TCTP) is a cytosolic protein with microtubule stabilization and calcium-binding activities. TCTP is expressed in most organs including the nervous system. However, detailed distribution and functional significance of TCTP in the brain remain unexplored. In this
G Thiel et al.
The Journal of biological chemistry, 265(27), 16527-16533 (1990-09-25)
The synapsins are a family of neuron-specific phosphoproteins that selectively bind to small synaptic vesicles in the presynaptic nerve terminal. Using the cDNA encoding rat synapsin IIb, we employed an Escherichia coli expression system to synthesize a variety of fusion
Yuhai Zhao et al.
Frontiers in cellular neuroscience, 13, 314-314 (2019-07-30)
Trans-synaptic neurotransmission of both electrical and neurochemical information in the central nervous system (CNS) is achieved through a highly interactive network of neuron-specific synaptic proteins that include pre-synaptic and post-synaptic elements. These elements include a family of several well-characterized integral-
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