PZ0267

WAY-362450

≥98% (HPLC)

• 別名: 3-(3,4-Difluoro-benzoyl)-1,1-dimethylene-1,2,3,6-tetrahydro-azepino [4,5-b]indole-5-carboxylic acid isopropyl ester, 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethyl-azepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester, FXR 450, Turofexorate isopropyl, WAY 362450, XL335
• 実験式（ヒル表記法）: C₂₅H₂₄F₂N₂O₃
• CAS番号: 629664-81-9
• 分子量: 438.47
• MDL番号: MFCD13181507
• UNSPSCコード: 12352200
• PubChem Substance ID: 329823801
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: room temp
• SMILES記法: FC1=C(F)C=C(C(N2CC(C)(C)C(C(C=CC=C3)=C3N4)=C4C(C(OC(C)C)=O)=C2)=O)C=C1
• InChI: 1S/C25H24F2N2O3/c1-14(2)32-24(31)17-12-29(23(30)15-9-10-18(26)19(27)11-15)13-25(3,4)21-16-7-5-6-8-20(16)28-22(17)21/h5-12,14,28H,13H2,1-4H3
• InChI Key: INASOKQDNHHMRE-UHFFFAOYSA-N
• 遺伝子情報: human ... NR1H4(9971)

詳細

生物化学的／生理学的作用

WAY-362450 is a potent and selective Farnesoid X receptor (FXR) agonist that lowers total plasma cholesterol (all lipoprotein species). WAY-362450 reduced the levels of high-density lipoprotein cholesterol (HDLc) in Cynomolgus monkeys, mice and hamsters. Apparently HDL lowering is achieved through increased transhepatic cholesterol efflux.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable