P7903

ピペミド酸

• 別名: 8-エチル-5,8-ジヒドロ-5-オキソ-2-(1-ピペラジニル)ピリド(2,3-d)ピリミジン-6-カルボン酸
• 実験式（ヒル表記法）: C₁₄H₁₇N₅O₃
• CAS番号: 51940-44-4
• 分子量: 303.32
• EC Number: 257-530-2
• MDL番号: MFCD00057291
• UNSPSCコード: 51282938
• PubChem Substance ID: 24898889
• NACRES: NA.85

特性

• 形状: powder
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria
• 作用機序: DNA synthesis | interferes; cell wall synthesis | interferes; enzyme | inhibits
• SMILES記法: CCN1C=C(C(O)=O)C(=O)c2cnc(nc12)N3CCNCC3
• InChI: 1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)
• InChI Key: JOHZPMXAZQZXHR-UHFFFAOYSA-N
• 遺伝子情報: human ... CYP1A2(1544)

詳細

詳細

Chemical structure: quinolone

アプリケーション

Pipemidic acid is used to study DNA damage and mutagenic activity. It has been used to induce articular lesions in the neonatal mouse and is used to study human lymphocyte blastogenesis and γ-interferon production .

生物化学的／生理学的作用

Pipemidic acid modulates (inhibits) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Pipemidic acid has been shown to induce inhibition of lymphocyte DNA synthesis.

アナリシスノート

Very slightly soluble in water. It dissolves in diluted solutions of acids and of alkali hydroxides.

その他情報

10g,100g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H317,H334
• 注意書き: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• 危険有害性の分類: Resp. Sens. 1 - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves