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由来生物
human brain
品質水準
アッセイ
≥95% (SDS-PAGE)
形状
buffered aqueous solution
比活性
≥10 units/mg protein
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
遺伝子情報
human ... ENO2(2026)
詳細
Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue.
アプリケーション
Neuron-specific enolase from human brain has been used in a study to assess human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia. It has also been used in a study to investigate sinonasal teratocarcinosarcoma with rhabdoid features.
生物化学的／生理学的作用
Neuron-specific enolase (NSE) is expressed in all neuronal cell types, and its expression marks the acquisition of synaptic function. Following acute neuronal injury, NSE levels are increased in neuronal cell bodies. Increased levels of NSE in serum and cerebrospinal fluid have been used as markers for injury and neuronal cell death. Tumors derived from many cell types, including most neuronal and neuroendocrine tumors, express NSE.
Neuron-specific enolase promotes survival of neurons and can provide neuroprotective effects by binding to neurons in a calcium-dependent manner.
単位の定義
1 unitは、pH 7.4、25°C、1分間で、1.0 μmoleの2-ホスホグリセリン酸をホスホ(エノール)ピルビン酸に変換します。
物理的形状
0.1 M Tris-リン酸(pH 7.0)、0.2 M KCl、5 mM NgSO4の溶液
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
N4773-VAR:
N4773-10UG:
N4773-BULK:
N4773-10UG-PW:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Jo-Heon Kim et al.
Pathology international, 61(12), 762-767 (2011-12-01)
Sinonasal teratocarcinosarcoma (SNTCS) is a very rare tumor developed in the nasal cavity and paranasal sinuses. The rhabdoid phenotype represents an aggressive biological behavior, but the rhabdoid feature has hitherto not been reported in cases of SNTCS. A 46-year-old man
Neuron-specific enolase is produced by neuroendocrine tumours
Tapia, F., et al.
Lancet, 317, 808-811 (1981)
Transplantation of human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia
Li, F., et al.
Molecular Medicine, 6, 625-630 (2012)
T Hattori et al.
Neuroscience research, 21(3), 191-198 (1995-01-01)
We previously reported that the gamma gamma-isozyme of enolase, NSE), one of the glycolytic enzymes, promoted the survival of embryonic rat neocortical neurons in culture, but alpha alpha-isozyme (non-neuronal enolase) had no effect. In the present study, the neurotrophic effects
Ai-tao Guo et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 41(11), 747-751 (2013-01-11)
To study the clinical and pathologic characteristics of small cell neuroendocrine carcinoma of urinary tract. All cases of urinary tract carcinoma encountered in the General Hospital of People Liberation Army during the period from 1999 to 2010 were retrospectively reviewed.
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