由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen 180 kDa
化学種の反応性
mouse, rat
テクニック
microarray: suitable
western blot: 0.5-1 μg/mL using a rat brain extract (S1 fraction)
western blot: 1-2 μg/mL using mouse brain (fraction S1).
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
mouse ... Ppp1r9a(243725)
rat ... Ppp1r9a(84685)
類似した製品をお探しですか？ 訪問 製品比較ガイド
詳細
Neurabin I is expressed in the central nervous system of rats.
Neurabin I or neural tissue-specific F-actin-binding protein is highly enriched in dendritic spines. It comprises the F-actin binding domain at the N-terminus, a single PDZ interacting-domain and a C-terminal coiled-coil domain. Neurabin I is localized in the synapse of mature neurons and the lamellipodia of the growth cone during neuronal development.
特異性
Anti-Neurabin I specifically recognizes neurabin I (180 kDa).
免疫原
synthetic peptide located near the N-terminus of rat neurabin I (amino acids 341-361). This sequence is highly conserved (80%) in mouse neurabin I and not found in neurabin II/spinophilin.
アプリケーション
Anti-Neurabin I antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
生物化学的／生理学的作用
Neurabin I has a role in the assembly of F-actin. It has been shown to be associated with stimulation of hepatocarcinogenesis in rats.
Neurabin I is essential for neurite formation and binds to several proteins including F-actin, protein phosphatase 1 (PP1), p70 S6 kinase (p70S6K) and TGN38. Neurabin I/PP1 complex has been suggested to play a role in actin cytoskeleton dynamics and also in the control of cell morphology in mammalian neurons. The interaction of neurabin I with the trans-Golgi network membrane protein (TGN38) enables a link between TGN38-containing membranes and the actin cytoskeleton. Neurabin′s presence in fetal tissue may mediate early development, through regulation of actin cytoskeleton dynamics in the differentiation of skeletal muscle cells.
ターゲットの説明
Neurabin I (Neural-tissue specific F-actin bindingprotein I, PP1BP175, p180, also termed Proteinphosphatase 1 regulatory subunit 9A, PPP1R9A, 180kDa), belongs to a family of F-actin-binding proteins, including neurabin II/spinophilin, which are high
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
保管および安定性
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our 製品選択ツール.
保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
N4412-VAR:
N4412-BULK:
N4412-200UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Crystal G Pontrello et al.
The open neuroscience journal, 3, 67-86 (2009-01-01)
Dendritic spines are actin-rich structures that accommodate the postsynaptic sites of most excitatory synapses in the brain. Although dendritic spines form and mature as synaptic connections develop, they remain plastic even in the adult brain, where they can rapidly grow
Anna Kakehashi et al.
Toxicological sciences : an official journal of the Society of Toxicology, 119(1), 61-72 (2010-10-12)
In the present study, protein lysates from microdissected glutathione S-transferase placental-form-positive (GST-P(+)) foci and hepatocellular carcinomas from livers of rats treated with N-diethylnitrosamine followed by phenobarbital at doses of 0 and 500 ppm in the diet for 10 and 33
Genomic imprinting of PPP1R9A encoding neurabin I in skeletal muscle and extra-embryonic tissues.
K Nakabayashi et al.
Journal of medical genetics, 41(8), 601-608 (2004-08-03)
D J Stephens et al.
The Journal of biological chemistry, 274(42), 30080-30086 (1999-10-09)
TGN38 is a type I integral membrane protein that constitutively cycles between the trans-Golgi network (TGN) and plasma membrane. The cytosolic domain of TGN38 interacts with AP2 clathrin adaptor complexes via the tyrosine-containing motif (-SDYQRL-) to direct internalization from the
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）