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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
化学種の反応性
human
濃度
1 mg/mL
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 2.5-7 μg/mL using human tissue
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
遺伝子情報
human ... MC1R(4157)
mouse ... Mc1r(17199)
詳細
Anti-Melanocortin 1 Receptor is produced in rabbit using as immunogen a synthetic peptide conjugated to KLH. The peptide corresponds to the third cytoplasmic loop of human Melanocortin 1 Receptor. The antibody is affinity-purified using the immunizing peptide immobilized on agarose.
Anti-Melanocortin 1 Receptor specifically recognizes human melanocortin 1 receptor by immunohistochemistry in formalin-fixed, paraffin-embedded tissues. Not tested for other uses. The immunizing peptide has 88% homology with the mouse gene. Other species reactivity has not been confirmed. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.
Anti-Melanocortin 1 Receptor specifically recognizes human melanocortin 1 receptor by immunohistochemistry in formalin-fixed, paraffin-embedded tissues. Not tested for other uses. The immunizing peptide has 88% homology with the mouse gene. Other species reactivity has not been confirmed. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.
免疫原
synthetic peptide corresponding to the third cytoplasmic loop of human melanocortin 1 receptor. The immunizing peptide has 88% homology with the mouse gene.
アプリケーション
Anti-Melanocortin 1 Receptor antibody produced in rabbit was used in immunoblotting for chondrocyte protein extracts at a dilution of 1:2000.
生物化学的／生理学的作用
Melanocortin 1 receptor (MC1R) is a G-protein coupled receptor that regulates the proliferation and differentiation of melanocytes. The melanocortin hormones activate MC1R that in turn triggers ERK1/2 pathway that promotes the synthesis of eumelanin pigments. Overexpression of MC1R is reported in a majority of human melanomas and acts as a marker in these tumor.
物理的形状
PBS溶液(pH 7.7, 0.1%アジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
M9193-VAR:
M9193-BULK:
M9193-50UL-PW:
M9193-50UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Judit Váradi et al.
PloS one, 12(1), e0170537-e0170537 (2017-01-20)
Alpha-melanocyte-stimulating hormone (α-MSH) is a potent anti-inflammatory peptide with cytoprotective effect in various tissues. The present investigation demonstrates the ability of α-MSH to interact with intestinal epithelial cell monolayers and mitigate inflammatory processes of the epithelial barrier. The protective effect
Marta Abrisqueta et al.
Journal of cell science, 126(Pt 16), 3724-3737 (2013-06-12)
The melanocortin 1 receptor (MC1R) is a G-protein-coupled receptor (GPCR) crucial for the regulation of melanocyte proliferation and differentiation. MC1R activation by melanocortin hormones triggers the cAMP pathway and stimulates the extracellular-signal-regulated protein kinases ERK1 and ERK2 to promote synthesis
A A Rosenkranz et al.
Biochemistry. Biokhimiia, 78(11), 1228-1237 (2014-01-28)
The conventional chemotherapeutic treatment of malignant melanoma still remains poorly efficient in most cases. Thus the use of specific features of these tumors for development of new therapeutic modalities is highly needed. Melanocortin 1 receptor (MC1R) overexpression on the cell
Magdalena K Kaneva et al.
British journal of pharmacology, 167(1), 67-79 (2012-04-05)
Melanocortin MC(1) and MC(3 ) receptors, mediate the anti-inflammatory effects of melanocortin peptides. Targeting these receptors could therefore lead to development of novel anti-inflammatory therapeutic agents. We investigated the expression of MC(1) and MC(3) receptors on chondrocytes
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