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由来生物
mouse
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
Munc13-71, monoclonal
形状
buffered aqueous solution
化学種の反応性
rat, mouse
濃度
~2 mg/mL
テクニック
microarray: suitable
western blot: 1-2 μg/mL using cytosolic rat brain S1 fraction
アイソタイプ
IgG2b
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
mouse ... Unc13a(382018)
rat ... Unc13a(64829)
詳細
Monoclonal Anti-Munc13-1 (mouse IgG2b isotype) is derived from the hybridoma Munc13-71 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a synthetic peptide of rat Munc13-1, conjugated to KLH. Protein unc-13 homolog A (Munc13-1) contains a diacylglycerol (DAG)/b phorbol ester-binding C1 domain. Munc13-1 are expression in axon is observed at various synapse populations.
Munc13/1 is a diacylglycerol receptor which is expressed in the presynaptic area.
免疫原
ラットMunc13/1のアミノ酸10-27に相当する合成ペプチドのKLH結合体。
アプリケーション
Monoclonal Anti-Munc13/1 antibody produced in mouse has been used in enzyme linked immunosorbent assay (ELISA) and immunoblotting.
生物化学的／生理学的作用
Munc13/1 has a crucial role in synaptic vesicle priming. It interacts with Syntaxin 1A and helps it to bind to soluble NSF attachment protein receptor (SNARE) proteins. Thus it contributes to the stability of the SNARE complex. Deletion of Munc13/1 leads to complete arrest synaptic transmission.
物理的形状
0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
M6194-200UL:
M6194-BULK:
M6194-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
ELKS/Voltage-dependent Ca2+ channel-beta subunit module regulates polarized Ca2+ influx in pancreatic beta cells
Ohara-Imaizumi M, et al.
Testing, 26(5), 1213-1226 (2019)
Differential control of vesicle priming and short-term plasticity by Munc13 isoforms
Rosenmund C, et al.
Neuron, 33(3), 411-424 (2002)
Stefan Kalla et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(50), 13054-13066 (2006-12-15)
GFP (green fluorescent protein) fusion proteins have revolutionized research on protein dynamics at synapses. However, corresponding analyses usually involve protein expression methods that override endogenous regulatory mechanisms, and therefore cause overexpression and temporal or spatial misexpression of exogenous fusion proteins
Lijun Kang et al.
Cell metabolism, 3(6), 463-468 (2006-05-16)
Munc13-1 is a presynaptic protein that is essential for synaptic vesicle priming. Deletion of Munc13-1/unc13 causes total arrest of synaptic transmission due to a complete loss of fusion-competent synaptic vesicles. The requirement of Munc13-1 for large dense-core vesicles (LDCVs), however
Edwin P Kwan et al.
Diabetes, 55(5), 1421-1429 (2006-04-29)
Munc13-1 is a diacylglycerol (DAG) receptor that is essential for synaptic vesicle priming. We recently showed that Munc13-1 is expressed in rodent and human islet beta-cells and that its levels are reduced in islets of type 2 diabetic humans and
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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