M4565

マトリックスメタロプロテアーゼ-7 ヒト

~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution

• 別名: MMP-7, マトリライシン-1
• Enzyme Commission number: 3.4.24.23 (BRENDA, IUBMB)
• MDL番号: MFCD01633460
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• リコンビナント: expressed in E. coli
• 品質水準: 200
• 形状: buffered aqueous solution
• 比活性: 5,000 units/mg protein
• 分子量: 20 kDa
• 濃度: ~0.1 mg/mL
• UniProtアクセッション番号: P09237
• 関連疾患: cancer
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... MMP7(4316)

詳細

詳細

Matrix metalloproteinase-7 (MMP7) also referred to as matrilysin is encoded by the gene mapped to human chromosome 11q21-q22. MMP7 is a smallest member of MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells.

アプリケーション

Matrix metalloproteinase-7 (MMP7) human has been used in in silico analysis of MMP-7 proteolysis of perlecan.

生物化学的／生理学的作用

Matrix metalloproteinase-7 (MMP-7) catalyzes the cleavage of extracellular matrix (ECM) proteins such as proteoglycans, fibronectin, entactin, laminin, collagen III/ IV/ V/ IX/ X/ XI, type I/ II/ IV/ V gelatins, and elastin. Matrix metalloproteinase-7 facilitates initial stages of tumor progression. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. Overexpression of MMP7 is observed in various human cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Increased expression of MMP7 is also associated with pathogenesis of demyelinating multiple sclerosis (MS) lesions. Both in silico and in vitro studies show that MMP7 degrades glycosylated and basement membrane bound perlecan and plays a vital role in prostate cancer cell invasion.

物理的形状

活性酵素を含む10mM HEPESバッファ-溶液 (pH 7.4, 0.15M塩化ナトリウム, 5mM塩化カルシウム含有)。

アナリシスノート

酵素活性1ユニットは、pH 7.5、37°Cで1分あたり1 mgのアゾコールを分解する量として定義されています。

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable