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品質水準
アッセイ
≥98% (HPLC)
形状
solid
色
yellow
溶解性
DMSO: ≥20 mg/mL
H2O: insoluble
保管温度
2-8°C
SMILES記法
CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)-n3ccnc3
InChI
1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3
InChI Key
XQABBHBFHWHMKF-UHFFFAOYSA-N
生物化学的／生理学的作用
ISCK03はin vitroで用量依存的にc-Kitのリン酸化を阻害します。ISCK03は、501melヒトメラノーマ細胞でSCF(幹細胞因子)誘導性のc-kitリン酸化を阻害します。完全阻害は1および5 μM ISCK03で観察されました。
特徴および利点
This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
保管分類コード
11 - Combustible Solids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
I6410-25MG:
I6410-5MG:
I6410-BULK:
I6410-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Rationale: Microphthalmia-associated transcription factor M (MITF-M) plays important roles in the pigment production, differentiation and survival of melanocytes. Stem cell factor (SCF) and its receptor KIT stimulate MITF-M activity via phosphorylation at the post-translation level. However, the phosphorylation shortens half-life
資料
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