H1142

15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid

~150 μg/mL in ethanol, ≥97.0% (HPLC)

• 別名: (15S,5Z,8Z,11Z,13E)-15-Hydroxyeicosatetraenoic acid, (S)-15-HETE, 15(S)-HETE
• 実験式（ヒル表記法）: C₂₀H₃₂O₃
• CAS番号: 54845-95-3
• 分子量: 320.47
• Beilstein: 2470466
• MDL番号: MFCD00063590
• UNSPSCコード: 12352200
• PubChem Substance ID: 24895431

特性

• アッセイ: ≥97.0% (HPLC)
• 濃度: ~150 μg/mL in ethanol
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O
• InChI: 1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1
• InChI Key: JSFATNQSLKRBCI-VAEKSGALSA-N

詳細

生物化学的／生理学的作用

Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.

安全性情報

• ピクトグラム: GHS02,GHS07
• シグナルワード: Danger
• 危険有害性情報: H225,H315,H319,H335
• 注意書き: P210 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 3
• 引火点(°F): 57.2 °F - closed cup
• 引火点(℃): 14 °C - closed cup
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter