F0552
Fasリガンド マウス由来
>95% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|---|---|
50 μg | 在庫from市川市大町368 | ￥134,000 |
この商品について
￥134,000
在庫詳細
高品質はそのまま、さらにお手頃な価格になりました
recombinant
expressed in mouse NSO cells
Quality Segment
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
monomer calculated mol wt ~18 kDa, 28-32 kDa by SDS-PAGE
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Fasl(14103)
General description
FASLG (Fas ligand) acts as a ligand for Fas receptor, and is a major protein involved in programmed cell death, apoptosis. Soluble Fas (sFAS) is usually detected in plasma prior to apoptosis.[1]
Application
Biochem/physiol Actions
FASLG (Fas ligand) and Fas receptor constitute the basic elements in apoptosis. Interaction of FASLG with Fas receptor leads to activation of caspase-8. This caspase in turn leads to activation of effector caspases such as caspase-3, -6 and -7. This cascade results in the hydrolysis of nuclear and cytoplasmic components. Expression of FASLG is induced by nuclear factor-κB (NFκB). NFκB/FASLG pathway facilitates the suppression of p,p′-DDT (dichlorodiphenoxytrichloroethane)-induced cell toxicity by vitamin C and E.[4] In CD4+ T cells, this protein is expressed on stimulus by T-cell receptor (TCR), both during normal and pathological conditions, such as alcohol exposure.[5]
Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).
Protein belonging to the tumor necrosis factor (TNF) family of cytokines; induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).
Physical form
凍結乾燥品(PBS溶液, 2.5 mg BSA, 0.2 μmフィルタ-減菌済み)。
Analysis Note
ジャ-カット細胞のアポト-シス誘導能により活性を測定しています。
Other Notes
マウスFASリガンド, アミノ酸残基132~279がコ-ドされています。N末端に6Xヒスチジンタグを付加しています。
1 of 1
当該品目 | |||
|---|---|---|---|
| recombinant expressed in mouse NSO cells | recombinant expressed in baculovirus infected Sf21 cells | recombinant expressed in NSO cells | recombinant expressed in NSO cells |
| assay >95% (SDS-PAGE) | assay >97% (SDS-PAGE) | assay >95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| impurities endotoxin, tested | impurities endotoxin, tested | impurities endotoxin, tested | impurities endotoxin, tested |
保管分類
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
F0552-BULK: + F0552-VAR: + F0552-50UG-PW: + F0552-50UG:
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