E8755

エリスロマイシンエチルスクシナート

• 実験式（ヒル表記法）: C₄₃H₇₅NO₁₆
• CAS番号: 1264-62-6
• 分子量: 862.05
• NACRES: NA.85
• PubChem Substance ID: 24894684
• UNSPSC Code: 51282328
• EC Number: 215-033-8
• MDL number: MFCD00084692

特性

• biological source: microbial
• form: solid
• potency: ≥780 μg per mg
• color: white
• solubility: ethanol: 50 mg/mL
• antibiotic activity spectrum: Gram-positive bacteria
• mode of action: protein synthesis | interferes
• SMILES string: CCOC(=O)CCC(=O)OC1C(CC(C)OC1OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)N(C)C
• InChI: 1S/C43H75NO16/c1-15-29-43(11,52)36(48)24(5)33(47)22(3)20-41(9,51)38(25(6)34(26(7)39(50)57-29)59-32-21-42(10,53-14)37(49)27(8)56-32)60-40-35(28(44(12)13)19-23(4)55-40)58-31(46)18-17-30(45)54-16-2/h22-29,32,34-38,40,48-49,51-52H,15-21H2,1-14H3
• InChI key: NSYZCCDSJNWWJL-UHFFFAOYSA-N

詳細

General description

Chemical structure: macrolide

Application

Erythromycin ethyl succinate is used to study erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae[1]. It has been used to study down-regulation of motilin receptors on rabbit colon myocytes[2] and lethal mutations in outer membrane genes omsA and firA in Salmonella typhimurium[3].

Biochem/physiol Actions

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.

安全性情報

• pictograms: GHS08
• signalword: Danger
• hcodes: H317,H334
• pcodes: P261 - P280 - P342 + P311
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• 保管分類: 11 - Combustible Solids
• wgk: WGK 2
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves