E1657
EHT 1864
≥98% (HPLC), Rac function inhibitor, powder
別名:
5-(5-(7-(トリフルオロメチル)キノリン-4-イルチオ)ペンチルオキシ)-2-(モルホリノメチル)-4H-ピラン-4-オン二塩酸塩
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|---|---|
10 mg | カートの在庫状況を確認する | ￥103,000 |
この商品について
実験式（ヒル表記法）:
C25H27F3N2O4S · 2HCl
CAS番号:
分子量:
581.47
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
製品名
EHT 1864, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
Cl.Cl.FC(F)(F)c1ccc2c(SCCCCCOC3=COC(CN4CCOCC4)=CC3=O)ccnc2c1
InChI
1S/C25H27F3N2O4S.2ClH/c26-25(27,28)18-4-5-20-21(14-18)29-7-6-24(20)35-13-3-1-2-10-33-23-17-34-19(15-22(23)31)16-30-8-11-32-12-9-30;;/h4-7,14-15,17H,1-3,8-13,16H2;2*1H
InChI key
LSECOAJFCKFQJG-UHFFFAOYSA-N
Application
EHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.
Biochem/physiol Actions
EHT 1864はRacの機能を阻害します。
EHT 1864はRacの機能を阻害します。in vitroにおいてγ-セクレターゼを直接阻害せずにAβ40やAβ42の産生を阻止します。
EHT 1864 induces dissociation of bound nucleotides. EHT 1864 induced inhibition of Rac prevents its association with downstream effectors. It is known to prevent estrogen-induced tumor cell proliferation in breast cancer.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
EHT 1864はExonHit Therapeutics S.A.(www.exonhit.com)の特許ライセンスを受けて販売を行っています。
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当該品目 | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form solid |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: 10 mg/mL, clear | solubility H2O: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: ≥10 mg/mL, H2O: insoluble |
| color white to beige | color white to beige | color white to beige | color white |
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)