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由来生物
goat
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
lyophilized powder
化学種の反応性
human
テクニック
flow cytometry: 3-10 μg/mL
immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.2 μg/mL
UniProtアクセッション番号
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... S100A12(6283)
詳細
EN-RAGE is a member of the S100/calgranulin superfamily.
免疫原
purified, E. coli-derived recombinant human extracellular RAGE-binding protein.
アプリケーション
Anti-EN-RAGE antibody produced in goat is suitable for western blot analysis at a working concentration of 0.1–0.2μg/mL, immunohistochemistry at 5-15μg/mL and flow cytometry at 3-10μg/mL/106 cells.
生物化学的／生理学的作用
The gene encodes a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It stimulates innate immune cells via binding to receptor for advanced glycation end products (AGER), which activates the MAP-kinase and NF-κ-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also stimulates mast cell degranulation and activation which generates chemokines, histamine and cytokines with leukocyte recruitment to the sites of inflammation.
物理的形状
凍結乾燥品(PBS溶液, 5%トレハロース含有, 0.2 μmフィルター滅菌済み)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
13 - Non Combustible Solids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Zheng Yang et al.
The Journal of allergy and clinical immunology, 119(1), 106-114 (2007-01-09)
The calcium-binding protein S100A12 might provoke inflammation and monocyte recruitment through the receptor for advanced glycation end products. Because inflammation elicited by S100A12 in vivo had characteristics of mast cell (MC) activation, we aimed to define the mechanism. Various MC
A M Cole et al.
FEBS letters, 504(1-2), 5-10 (2001-08-28)
The human airways are protected from pathogenic colonization by a blanket of fluid impregnated with innate antimicrobial effector molecules. Among several previously uncharacterized components, we isolated a peptide that had activity primarily targeting Gram-negative bacteria. We named the peptide 'calcitermin'
Olga V Moroz et al.
BMC biochemistry, 10, 11-11 (2009-04-24)
Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders. S100A12 is an important factor in host/parasite defenses and in the inflammatory response. Like
Wei Xing Yan et al.
The Journal of biological chemistry, 283(19), 13035-13043 (2008-02-23)
S100A12 is expressed at sites of acute, chronic, and allergic inflammation. S100 proteins have regions of high sequence homology, but the "hinge" region between the conserved calcium binding domains is structurally and functionally divergent. Because the murine S100A8 hinge domain
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