D7191

Dibenzylfluorescein

• 別名: DBF
• 実験式（ヒル表記法）: C₃₄H₂₄O₅
• 分子量: 512.55
• UNSPSC Code: 12171500
• PubChem Substance ID: 329798844
• MDL number: MFCD13184323

特性

• assay: 99-102% (NMR)
• Quality Segment: 200
• form: solid
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: O=C1C=CC2=C(c3ccc(OCc4ccccc4)cc3OC2=C1)c5ccccc5C(=O)OCc6ccccc6
• InChI: 1S/C34H24O5/c35-25-15-17-29-31(19-25)39-32-20-26(37-21-23-9-3-1-4-10-23)16-18-30(32)33(29)27-13-7-8-14-28(27)34(36)38-22-24-11-5-2-6-12-24/h1-20H,21-22H2
• InChI key: YZJGKSLPSGPFEV-UHFFFAOYSA-N

詳細

Application

DBF is dealkylated by cytochromes P450 (especially CYP2C8, CYP2C9, CYP2C19, and CYP3A) to form a fluorescein ester. Dibenzylfluorescein was reported to be suitable for in vitro assessment of the initial screening of CYP3A4-
mediated drug interactions. The fluorescent fluorescein product can be quantitated after the addition of base, which hydrolyzes the ester and increases the pH for optimal fluorescein fluorescence detection.

DBF is dealkylated by cytochromes P450 (especially CYP2C8, CYP2C9, CYP2C19, and CYP3A) to form a fluorescein ester. The fluorescent fluorescein product can be quantitated after the addition of base, which hydrolyzes the ester and increases the pH for optimal fluorescein fluorescence detection.

Other Notes

Dibenzylfluorescein is light sensitive and should be protected from direct sunlight or UV sources.

安全性情報

• ピクトグラム: GHS07
• 注意喚起語: Warning
• ハザードコード: H302 + H312 + H332
• 注意事項: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Oral
• 保管分類: 11 - Combustible Solids
• 一体何が起きているの？: WGK 3
• PPE（個人用保護具）: dust mask type N95 (US), Eyeshields, Gloves