This product is a 2 mg/mL solution of Doxorubicin in pure DMSO. The material has not been specifically test for use in TNBC cells. In general, the final DMSO concentrations in cell culture medium should not exceed 0.5%. This product is prepared using Doxorubicin HCl with a molecular weight of 579.98. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/281/732/d5220pis-rev0922-ms.pdf
D5220
Doxorubicin Ready-Made
2mg/ml, Suitable for cell culture
別名:
Adriamycin, DOX, Hydroxydaunorubicin hydrochloride
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|
この商品について
NACRES:
NA.76
UNSPSC Code:
12352200
現在、価格および在庫状況を閲覧できません。
Quality Segment
form
liquid
mol wt
579.98 Da
packaging
pkg of 1 mL
concentration
2 mg/mL
shipped in
dry ice
storage temp.
-10 to -25°C
Biochem/physiol Actions
Doxorubicin is an antitumor antibiotic that acts by inhibiting DNA topoisomerase II. It intercalates with DNA and induces apoptosis by blocking replication.
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当該品目 | |||
|---|---|---|---|
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| form liquid | form liquid | form powder | form powder |
| concentration 2 mg/mL | concentration - | concentration - | concentration - |
| storage temp. -10 to -25°C | storage temp. −70°C | storage temp. 2-8°C | storage temp. -10 to -25°C |
| shipped in dry ice | shipped in - | shipped in - | shipped in - |
| mol wt 579.98 Da | mol wt - | mol wt - | mol wt - |
保管分類
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
D5220-BULK: + D5220-1ML: + D5220-VAR:
jan
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I am considering using this ready made solution for my cellular assays aiming to induce senescence into TNBC cell lines. I am wondering what the molarity is for this ready made product and if there are any concerns surrounding the volume of DMSO?
1 回答-
役に立ちましたか？
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What is the molecular formula of the doxorubicin HCl used in this solution?
1 回答-
The Doxorubicin HCl used to prepare this product has a molecular formula of C27H29NO11 · HCl. See product D1515 at the link below for additional details:
https://www.sigmaaldrich.com/product/sigma/d1515役に立ちましたか？
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la solution de "doxorubicin ready-made" (ref D5220) est diluée dans un buffer: quelle est sa composition ? (sels de phosphates ? ou autre)
1 回答-
This readymade solution contains doxorubicin hydrochloride at a concentration of 2 mg/mL in DMSO. Further information is available under "More Documents" or at this link: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/281/732/d5220pis-rev0922-ms.pdf.
役に立ちましたか？
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When this substance is diluted and stored at -10°C to -25°C, what is the recommended storage duration?
1 回答-
This product is stable for at least 2 years in the undiluted state. Stability studies have not been performed on the material when diluted in aqueous solutions. Please see the link below to review a publication that may be helpful.
https://pubmed.ncbi.nlm.nih.gov/517541/役に立ちましたか？
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What this product is dissolved in? Is it dissolved in water ?
1 回答-
This Ready-Made solution contains doxorubicin hydrochloride at a concentration of 2 mg/mL in DMSO. This solution may be diluted further with buffer or medium.
役に立ちましたか？
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