C6022

シプロヘプタジン 塩酸塩 セスキ水和物

≥98% (TLC), solid

• 別名: ピペリジン, 4-(5H-ジベンゾ[a,d]シクロヘプテン-5-イリデン)-1-メチル-, 塩酸塩, 水和物(2:3)
• 実験式（ヒル表記法）: C₂₁H₂₁N·HCl·1.5H₂O
• CAS番号: 41354-29-4
• 分子量: 350.88
• EC Number: 213-535-1
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278082
• NACRES: NA.77

特性

• アッセイ: ≥98% (TLC)
• 形状: solid
• 色: white to slightly yellow
• 溶解性: ethanol: soluble; methanol: soluble
• オーガナイザー: Merck & Co., Inc., Kenilworth, NJ, U.S.
• SMILES記法: Cl.CN1CCC(\CC1)=C2/c3ccccc3C=Cc4ccccc24
• InChI: 1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H,12-15H2,1H3;2*1H;3*1H2
• InChI Key: ZEAUHIZSRUAMQG-UHFFFAOYSA-N
• 遺伝子情報: human ... HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

詳細

アプリケーション

Cyproheptadine hydrochloride sesquihydrate has been used in:

• testing anti-inflammatory activity in serotonin receptor (5-HT) induced inflammation
• the inhibition of 5-HT in in vivo and in vitro bioassays in crabs
• the inhibition of 5-HT in embryo physiological experiments

inhibition of calcitonin gene related peptide (CGRP)

生物化学的／生理学的作用

Cyproheptadine hydrochloride sesquihydrate is a serotonin receptor (5-HT2/5-HT1C) antagonist, H1 histamine receptor antagonist and an antipruritic. The inhibition of 5-HT by cyproheptadine improves cognitive function in schizophrenia disorder. Cyproheptadine is effective for treating functional gastrointestinal disorders (FGIDs). Food and Drug Administration (FDA) approved cyproheptadine, has antidepressant and antiplatelet functionality. It may be effective in treating thromboembolic disorders. Cyproheptadine inhibits lysine methyltransferase 7/9 (Set7/9) leading to a decrease in estrogen receptor (ERα) expression and growth arrest in breast cancer cells.

特徴および利点

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H319,H335
• 注意書き: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves