C5740

シトクロムP450 ヒト

2E1 isozyme microsomes, with P450 Reductase and cytochrome b₅, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

• UNSPSC Code: 12352202
• NACRES: NA.61
• EC Number: 1.6.2.4 (BRENDA, IUBMB)
• MDL number: MFCD03456520
• Biological source: human
• Recombinant: expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

特性

• biological source: human
• Quality Segment: 200
• recombinant: expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
• description: 1.0 nmole P450 2E1 per 0.5 ml vial
• form: buffered aqueous solution (100 mM potassium phosphate, pH 7.4)
• UniProt accession no.: P05181
• application(s): cell analysis
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... CYP2E1(1571)

詳細

Application

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Alterations in the renal formation of Cytochrome P450 metabolites from arachidonic acid may participate in the formation of hypertension. Therefore, they have been identified as candidate mediators in the development of this multifactorial disease.

Biochem/physiol Actions

シトクロムP450は、異種アイソザイムのファミリーであり、その主な機能は、中間代謝(脂肪酸など)の一機能として、および外因性化合物(薬物または毒物)を解毒するために、低分子を酸化することです。一部のアイソフォームは、対象の狭い基質特異性を有しますが、他のアイソフォームには特異性はみられません。

Analysis Note

ロットにより、チトクロ-ムｃリダクタ-ゼ、チトクロ-ムb₅、チトクロ-ムP450の含有および、p-ニトロフェノ-ルヒドロキシラ-ゼ活性が報告されています。

安全性情報

• 保管分類: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)