BM0012

BMS-191095 hydrochloride

≥98% (HPLC)

• 別名: (3R,4S)-4-[(4-Chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile monohydrochloride, (3R-trans)-4-[(4-Chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-Benzopyran-6-carbonitrile monohydrochloride, BMS 191095 hydrochloride
• 実験式（ヒル表記法）: C₂₂H₂₁ClN₄O₂ · HCl
• CAS番号: 166095-95-0
• 分子量: 445.34
• MDL番号: MFCD00953840
• UNSPSCコード: 12352202
• PubChem Substance ID: 329774356
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: room temp
• SMILES記法: CC1(C)OC2=CC=C(C#N)C=C2[C@H](N(CC3=NC=CN3)C4=CC=C(Cl)C=C4)[C@H]1O.[H]Cl
• InChI: 1S/C22H21ClN4O2.ClH/c1-22(2)21(28)20(17-11-14(12-24)3-8-18(17)29-22)27(13-19-25-9-10-26-19)16-6-4-15(23)5-7-16;/h3-11,20-21,28H,13H2,1-2H3,(H,25,26);1H/t20-,21+;/m0./s1
• InChI Key: TZLMTXNZECPICU-JUDYQFGCSA-N

詳細

生物化学的／生理学的作用

BMS-191095 is a potent and selective mitochondrial ATP-sensitive K1 channel (KATP) channel opener devoid of peripheral vasodilating activity.

BMS-191095 is a potent and selective mitochondrial ATP-sensitive K1 channel (KATP) channel opener devoid of peripheral vasodilating activity. BMS-191095 improves postischemic recovery of function and reduced lactate dehydrogenase release in the isolated rat hearts.

特徴および利点

BMS-191095 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

法的情報

Sold for research purposes only under agreement from BMS.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable