AV31592

Anti-AEBP1 antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-AE binding protein 1
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: 131 kDa
• 化学種の反応性: rabbit, horse, guinea pig, rat, human
• 濃度: 0.5 mg - 1 mg/mL
• テクニック: immunohistochemistry: suitable; western blot: suitable
• NCBIアクセッション番号: NP_001120
• UniProtアクセッション番号: Q8IUX7
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... AEBP1(165)

詳細

詳細

AEBP1 is a transcriptional repressor that negatively regulates PTEN. This transcription factor is involved in adipocyte growth and is a sex-specific risk factor for diet-induced obesity. Furthermore, AEBP1 is also known to have proinflammatory roles in macrophages.
Rabbit Anti-AEBP1 antibody recognizes human, mouse, rat, and pig AEBP1.

The previously assigned protein identifier Q14113 has been merged into Q8IUX7. Full details can be found on the UniProt database.

免疫原

Synthetic peptide directed towards the N terminal region of human AEBP1

アプリケーション

Rabbit Anti-AEBP1 antibody can be used for immunohistochemical assays at concentration of 4-8μg/ml. It can also be used for western blot (0.2-5.0μg/ml) applications.

生物化学的／生理学的作用

The adipocyte enhancer binding protein 1 (AEBP1) is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. AEBP1 may play a role in differentiated vascular smooth muscle cells.

シーケンス

Synthetic peptide located within the following region: VPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEK

物理的形状

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable