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由来生物
rabbit
品質水準
抗体製品の状態
Ig fraction of antiserum
クローン
monoclonal
詳細
For In Vitro Diagnostic Use in Select Regions (See Chart)
形状
buffered aqueous solution
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
アイソタイプ
IgG
輸送温度
wet ice
保管温度
2-8°C
視覚化
cytoplasmic
詳細
Galectin-3 (GAL3), encoded by LGALS3, is a member of the galectin family of β-galactoside-binding lectins. GAL3 is involved in many biological process, such as cell growth and differentiation, cell-cell and cell-matrix adhesion interactions, angiogenesis, and apoptosis. It is expressed in normal breast epithelial cells, inflammatory and various malignant cells. Recent investigators have found GAL3 involved in tumor progression and metastasis, and its expression valuable in differentiating between benign and malignant thyroid neoplasms. Thyroid carcinomas are histologically classified into four subtypes: papillary, follicular, medullary, and anaplastic/undifferentiated. The papillary and follicular carcinomas are derived from follicular epithelium while the medullary subtype is derived from parafollicular cells (C cells). Anaplastic carcinoma also originates from follicular epithelium, but are highly aggressive. GAL3 was expressed in most thyroid malignancies of epithelial origin from fine-needle aspirate and open biopsies. GAL3 did not stain normal thyroid tissues or benign follicular adenomas. In a panel of 5 diagnostic markers (GAL3, FN1, CITED1, CK19, and HBME1), GAL3 demonstrated the highest sensitivity and accuracy in the differential diagnosis of benign and malignant tumors with follicular architecture. Fibronectin 1 (FN1) and GAL3 co-expression was diagnostic of carcinoma; their absence was indicative for benign lesions. GAL3 may be a useful marker for thyroid carcinomas of follicular cell origin (including papillary, follicular, and anaplastic carcinomas).
品質
 IVD |  IVD |  IVD |  RUO |
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &< 0.1% Sodium Azide
その他情報
For a copy of the IFU and CofA contact IVDorder@ABCAM.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
AC-0361:
試験成績書（COA）
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