A9486

AG-09/1

≥98% (HPLC)

• 別名: 2-[(6-メトキシ-1H-ベンゾイミダゾール-2-イル)チオ]-N-(4-ニトロフェニル)-アセトアミド
• 実験式（ヒル表記法）: C₁₆H₁₄N₄O₄S
• CAS番号: 356776-32-4
• 分子量: 358.37
• MDL番号: MFCD02321063
• UNSPSCコード: 12352202
• PubChem Substance ID: 329771051
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: yellow to brown
• 溶解性: DMSO: ≥30 mg/mL
• 保管温度: 2-8°C
• SMILES記法: COc1ccc2[nH]c(SCC(=O)Nc3ccc(cc3)[N+]([O-])=O)nc2c1
• InChI: 1S/C16H14N4O4S/c1-24-12-6-7-13-14(8-12)19-16(18-13)25-9-15(21)17-10-2-4-11(5-3-10)20(22)23/h2-8H,9H2,1H3,(H,17,21)(H,18,19)
• InChI Key: LYQDSNOFTIZWAX-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

AG-09/1 is a selective formyl peptide receptor 1 (FPR1) agonist; it activates chemotaxis in human neutrophils. Formyl peptide recetors (FPRs) are GPCRs mainly expressed in phagocytic leukocytes but with lower expression in many other cell types. Formyl peptides, act as Alarmins and are released from bacteria and damaged mitochondria, serving as chemoattractants for phagocyte recruitment to sites of inflammation, resulting in immune response. Because the endogenous ligands for FPRs are peptides and arachidonic acid metabolites, there are few small molecule tools for these receptors. A recent HTS of commercially available libraries yielded several FPR-1 selective agonists, of which AG-091 was the most potent. AG-091 induced intracellular calcium flux in FPR-1- but not FPR-2-expressing cells. It also caused chemotaxis and intracellular calcium flux in human leukocytes. AG-091 is a valuable tool for studying FPR1 function in immune and other disease states.

安全性情報

• ピクトグラム: GHS05
• シグナルワード: Danger
• 危険有害性情報: H318
• 注意書き: P280 - P305 + P351 + P338
• 危険有害性の分類: Eye Dam. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable