A8849
α2-アンチプラスミン ヒト血漿由来
lyophilized powder, ≥5 units/mg protein
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|
この商品について
Form:
lyophilized powder
Biological source:
human plasma
現在、価格および在庫状況を閲覧できません。
biological source
human plasma
Quality Segment
form
lyophilized powder
specific activity
≥5 units/mg protein
packaging
vial of ≥0.5 mg (Protein based on E1%/280 = 6.7)
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... SERPINF2(5345)
General description
α2-Antiplasmin (α2AP) is a glycoprotein and a member of the serine protease inhibitor (serpin) family. The protein is mainly synthesized in the liver and found in the kidney and brain. The serpin peptidase inhibitor, clade F member 2 (SERPINF2) gene is mapped to human chromosome 17p13.3.[1]
Application
α2-Antiplasmin from human plasma has been used as a protease inhibitor to treat human microvascular endothelial cells (HMEC-1) and demonstrate the role of factors responsible for endothelial cells detachment.[2] It has also been used to study its effect on the release of proteolytic activity under reducing conditions in therapeutic human serum albumin-containing products with a new neoepitope endopeptidase immunoassay.[3]
Biochem/physiol Actions
α2-Antiplasmin (α2AP) is an antifibrinolytic protein and an important inhibitor of plasmin. α2AP mediates clot formation by covalently cross-linking with the glutamine and the lysine residue of fibrin clot via activated factor XIII (FXIIIa). This prevents the clot from extreme degradation by plasmin. An inborn insufficiency of α2AP results in an autosomal recessive condition leading to a rare bleeding disorder. The severity of the bleeding condition is defined by the individual′s genetic variation. Studies show lower levels of α2AP associated with disseminated intravascular coagulation (DIC) and thrombolytic therapy. Elevated levels of α2AP have been reported in a patient with ischemic stroke.[1]
Physical form
ビス-トリス緩衝液と塩化ナトリウムを含む凍結乾燥粉末。
Other Notes
1 unitは、Val-Leu-Lys-p-ニトロアニリドを用い、37°C、pH7.2で、2 unitsのプラスミンの活性を50%低下させます。
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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当該品目 | |||
|---|---|---|---|
| biological source human plasma | biological source human plasma | biological source human | biological source human plasma |
| form lyophilized powder | form lyophilized powder | form lyophilized | form lyophilized powder |
| specific activity ≥5 units/mg protein | specific activity - | specific activity - | specific activity - |
| Gene Information human ... SERPINF2(5345) | Gene Information human ... AHSG(197) | Gene Information human ... SERPINC1(462) | Gene Information - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
A8849-.5MG-PW: + A8849-BULK: + A8849-VAR: + A8849-.5MG:
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