A3481

抗ApoER2 ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-Apolipoprotein E Receptor 2, Anti-LRP8, Low Density Lipoprotein Receptor-Related Protein 8 (LRP8)
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~105 kDa
• 化学種の反応性: human
• 強化検証: recombinant expression; Learn more about Antibody Enhanced Validation
• テクニック: western blot: 0.5-1 μg/mL using HEK-293T cells expressing human ApoER2
• UniProtアクセッション番号: Q14114
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... LRP8(7804)

詳細

詳細

Apolipoprotein E receptor 2 (ApoER2, also known as LRP8) is expressed predominantly in the brain and placenta. This gene is located on human chromosome 1p32.

The low-density lipoprotein receptor-related protein 8 (LRP8) or ApoER2 is a member of the LDL receptor family which includes LDLR and VLDLR. These proteins are involved in the uptake of lipid rich proteins into cells and cell signaling. ApoER2 assists in endocytosis and signal transduction.

特異性

Rabbit anti-ApoER2 antibody recognizes human ApoER2 by immunoblotting (approx. 105kDa). Staining of the ApoER2 band in immunoblotting is specifically inhibited by the ApoER2 immunizing peptide.

免疫原

synthetic peptide corresponding to amino acids 928-945 located near the C-terminus of human ApoER2, conjugated to KLH. This sequence is identical in mouse ApoER2.

アプリケーション

Anti-ApoER2 antibody produced in rabbit has been used in western blot analysis.

生物化学的／生理学的作用

Apolipoprotein E receptor 2 (ApoER2, also known as LRP8) play an important role in the endocytosis of plasma lipoproteins, including ApoE and cholesterol metabolism. In the central nervous system, ApoER2 mediates various neuronal signaling mechanisms during neuronal development, affecting neurite outgrowth, synapse formation and neuronal migration, and neuronal survival in response to acute damage. ApoER2 plays a central role in the reelin/Dab1 signaling pathway that controls neuronal positioning during brain development as well as long-term potentiation (LTP) in the adult brain.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)