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Merck
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主要文書

安全性情報

422R-1

Sigma-Aldrich

PHOX2B (EP312) Rabbit Monoclonal Primary Antibody

別名:

Paired-like Homeobox 2B

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About This Item

UNSPSCコード:
12352203
クローン:
EP312, monoclonal
application:
IHC (p)
化学種の反応性:
human
テクニック:
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
citations:
5

由来生物

rabbit

品質水準

100
500

結合体

unconjugated

抗体製品の状態

culture supernatant

抗体製品タイプ

primary antibodies

クローン

EP312, monoclonal

詳細

For In Vitro Diagnostic Use in Select Regions

フォーム

buffered aqueous solution

化学種の反応性

human

包装

vial of 0.1 mL concentrate (422R-14)
vial of 0.1 mL concentrate Research Use Only (422R-14-RUO)
vial of 0.5 mL concentrate (422R-15)
vial of 1.0 mL concentrate (422R-16)
vial of 1.0 mL concentrate Research Use Only (422R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (422R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (422R-17)
vial of 7.0 mL pre-dilute ready-to-use (422R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (422R-18-RUO)

メーカー/製品名

Cell Marque

テクニック

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

アイソタイプ

IgG

コントロール

neuroblastoma

輸送温度

wet ice

保管温度

2-8°C

視覚化

nuclear

遺伝子情報

human ... PHOX2B(8929)

詳細

Paired-like homeobox 2B (PHOX2B) is a transcription factor located on chromosome 4p13 which is crucial to the formation of autonomic ganglia in the autonomic nervous system (ANS). PHOX2B gene is strictly expressed in neural crest derivatives committed to the noradrenergic phenotype. The PHOX2B gene encodes a paired-like homeo-domain transcription factor with an extra-axial expression pattern restricted to the ANS. Neuroblasts of peripheral neuroblastic tumors are derived from the sympathoadrenal lineage, a division of the ANS. PHOX2B has been observed in peripheral neuroblastic tumors, neuroblastomas, paragangliomas, ganglioneuroblastomas, ganglioneuromas and pheochromocytomas. PHOX2B has been reported to be negative in other small round blue cell tumors.

品質


IVD

IVD

IVD

RUO

関連事項

PHOX2B Positive Control Slides, Product No. 422S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

調製ノート

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その他情報

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法的情報

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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保管分類コード

12 - Non Combustible Liquids

WGK

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

422R-11:
422R-14:
422R-17:
422R-15-RUO:
422R-12:
422R-16-RUO:
422R-18:
422R-15:
422R-16:
422R-13:
422R-17-RUO:
422R-18-RUO:
422R-14-RUO:


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試験成績書(COA)

Lot/Batch Number

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Franck Bourdeaut et al.
Cancer letters, 228(1-2), 51-58 (2005-06-14)
Hereditary predisposition to neuroblastoma accounts for less than 5% of neuroblastomas and is probably heterogeneous. Recently, a predisposition gene has been mapped to 16p12-p13, but has not yet been identified. Occurrence of neuroblastoma in association with congenital central hypoventilation and
Franck Bielle et al.
The American journal of surgical pathology, 36(8), 1141-1149 (2012-07-14)
Peripheral neuroblastic tumors are the most commonly occurring extracranial tumors in children. Although a reliable diagnosis is achievable in the majority of cases, diagnosis of a minority of peripheral neuroblastic tumor cases (especially undifferentiated neuroblastoma) poses a challenge compared with
A Pattyn et al.
Nature, 399(6734), 366-370 (1999-06-09)
The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system, and are all derived from the neural crest. The factors needed for these structures to develop include the transcription factor Mash1, the glial-derived neurotrophic
Daisuke Nonaka et al.
The American journal of surgical pathology, 37(8), 1236-1241 (2013-05-30)
Autonomic neurons and chromaffin cells, which constitute the autonomic nervous system, are derived from a common progenitor from the neural crest, and its development is controlled by a network of transcription factors, including the master regulator, Phox2b, and its downstream
L Longo et al.
International journal of oncology, 33(5), 985-991 (2008-10-25)
The detection of PHOX2B mutations in a small proportion of patients affected with either familial or sporadic neuroblastoma (NB), has arisen interest on the possible pathogenic role of this gene in the disease determination. In this light, we have carried

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