383A-7

SOX-10 Rabbit Polyclonal Antibody

unconjugated, Cell Marque^™

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100; 500
• 結合体: unconjugated
• 抗体製品の状態: Ig fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 詳細: For In Vitro Diagnostic Use in Select Regions (See Chart)
• 形状: buffered aqueous solution
• 化学種の反応性: human
• 包装: vial of 0.1 mL concentrate (383A-74); vial of 0.5 mL concentrate (383A-75); bottle of 1.0 mL predilute (383A-77); vial of 1.0 mL concentrate (383A-76); bottle of 7.0 mL predilute (383A-78)
• メーカー／製品名: Cell Marque^™
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• コントロール: melanoma, schwannoma, skin melanocytes
• 輸送温度: wet ice
• 保管温度: 2-8°C
• 視覚化: nuclear
• 遺伝子情報: human ... SOX10(6663) ; mouse ... Sox10(20665)

詳細

詳細

Sry-related HMG-BOX gene 10, (SOX-10), a nuclear transcription factor that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage, has been recently shown to be a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. SOX-10 nuclear expression was found in 76 of 78 melanomas (97%) and 38 of 77 malignant peripheral nerve sheath tumors (49%), whereas S100 protein was expressed in 71 melanomas (91%) and 23 malignant peripheral nerve sheath tumors (30%). SOX-10 was expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells which usually express S100 protein. It is known that the commonly used melanoma markers, anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while it has been reported that anti-SOX-10 was moderately to strongly expressed in all of the 28 desmoplastic melanomas tested. SOX-10 is less likely expressed by background fibrocytes and histiocytes in exicion scar than S100 and MiTF. Therefore, anti-SOX-10 is considered a very reliable marker for recognizing residual demoplastic melanoma.

SOX-10 is diffusely expressed in schwannomas and neurofibromas. SOX-10 reaction is not identified in any other mesenchymal and epithelial tumors except for myoepitheliomas and diffuse astrocytomas. SOX-10 expression is seen in sustentacular cells of pheochromocytomas and paragangliomas, and occasionally carcinoid tumors from various organs, but not in the tumor cells.

In normal tissues, SOX-10 is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial, eccrine, and mammary glands. SOX-10 expression is also observed in mast cells in a variety of tissues and organs in both nuclear and cytoplasmic reaction.

品質

IVD

IVD

IVD

RUO

関連事項

SOX-10 Positive Control Slides, Product No. 383S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

調製ノート

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

その他情報

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法的情報

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable