30960

デオキシコール酸

≥99.0% (T)

• 別名: 3α,12α-ジヒドロキシ-5β-コラン酸, 7-デオキシコール酸, デスオキシコール酸
• 実験式（ヒル表記法）: C₂₄H₄₀O₄
• CAS番号: 83-44-3
• 分子量: 392.57
• Beilstein: 3219882
• EC Number: 201-478-5
• MDL番号: MFCD00003673
• UNSPSCコード: 12352106
• PubChem Substance ID: 329753610
• NACRES: NA.77

特性

• 由来生物: ox bile
• 品質水準: 100
• 詳細: anionic
• アッセイ: ≥99.0% (T)
• フォーム: powder
• 光学活性: [α]20/D +54±1°, c = 1% in ethanol
• 分子量: 392.57 g/mol
• 不純物: ≤1% cholic acid (TLC)
• mp: 170-175 °C; 171-174 °C (lit.)
• 官能基: carboxylic acid
• SMILES記法: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
• InChI: 1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1
• InChI Key: KXGVEGMKQFWNSR-LLQZFEROSA-N
• 遺伝子情報: human ... ATIC(471)

詳細

詳細

Deoxycholic acid is an amphiphilic molecule and an important constituent of bile acid. It contains hydroxyl groups substituted at the 3α and 12α positions and a carboxyl group towards the end of the branched-chain. These moieties contribute to the hydrophilic nature of the molecule and the hydrophobic cyclopentanophenanthrene forms its center.

アプリケーション

Deoxycholic acid has been used as:

• a hyphal-inhibitory compound in an ex vivo assay to study the hyphal morphogenesis of Candida albicans in the gastrointestinal tract
• an internal standard to estimate the toxin concentration in the cell pellet
• a bile acid (BA) standard to quantitatively measure BA in various samples from treated mice by ultra-performance liquid chromatography triple quadrupole mass spectrometry

生物化学的／生理学的作用

Deoxycholic acid, due to its amphiphilicity, significantly helps to solubilize, emulsify, and absorb fat, vitamins, and cholesterol in the body. High levels of intestinal deoxycholic acid might cause colorectal cancer by inducing oxidative stress and leading to DNA damage. It acts as an oncogene and pro-tumor factor.

その他情報

β-アドレナリン受容体の可溶化

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H315,H319,H335
• 注意書き: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves