PHR1625

ルフィナミド

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: ルフィナミド, 1-[(2,6-ジフルオロフェニル)メチル]-1H-1,2,3-トリアゾール-4-カルボキサミド
• 実験式（ヒル表記法）: C₁₀H₈F₂N₄O
• CAS番号: 106308-44-5
• 分子量: 238.19
• MDL番号: MFCD00865314
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823517
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to USP 1606401
• APIファミリー: rufinamide
• CofA: current certificate can be downloaded
• 包装: pkg of 500 mg
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-30°C
• SMILES記法: NC(=O)c1cn(Cc2c(F)cccc2F)nn1
• InChI: 1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)
• InChI Key: POGQSBRIGCQNEG-UHFFFAOYSA-N
• 遺伝子情報: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

詳細

詳細

Rufinamide is an antiepileptic drug, used as an adjunctive for the treatment of seizures associated with Lennox−Gastaut syndrome. Its mode of action involves prolonging the refractory period of voltage-dependent sodium channels via stabilization of the sodium channel inactive state, thus effectively keeping the ion channels closed.

アプリケーション

Rufinamide may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

広域性の抗けいれん薬です。

診断上の意義

Effective therapy for partial seizures in adults and childhood seizures in Lennox-Gastaut syndrome.

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA5294 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H336,H351,H361fd
• 注意書き: P202 - P261 - P271 - P280 - P304 + P340 + P312 - P308 + P313
• 危険有害性の分類: Carc. 2 - Repr. 2 - STOT SE 3
• ターゲットの組織: Central nervous system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable