917648

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride

≥95%

• 別名: Semi-flexible linker for PROTAC^® development
• 実験式（ヒル表記法）: C₁₂H₁₈ClNO
• CAS番号: 1187927-60-1
• 分子量: 227.73
• MDL番号: MFCD11506185
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95%
• 形状: powder
• 反応適合性: reagent type: linker
• 官能基: hydroxyl
• 保管温度: 2-8°C
• SMILES記法: OCC1=CC=C(C2CCNCC2)C=C1.Cl
• InChI: 1S/C12H17NO.ClH/c14-9-10-1-3-11(4-2-10)12-5-7-13-8-6-12;/h1-4,12-14H,5-9H2;1H
• InChI Key: JSCRYCUDRVBGRN-UHFFFAOYSA-N

詳細

アプリケーション

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

その他情報

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable