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由来生物
human
品質水準
包装
vial of ≥1X10⁶ vial
メーカー/製品名
Millipore
テクニック
cell culture | mammalian: suitable
輸送温度
liquid nitrogen
保管温度
−196°C
アプリケーション
- Each vial contains > 1X106 viable cells.
- Cells are tested negative for infectious diseases by a Essential CLEAR Panel by Charles River Animal Diagnostic Services.
- Cells are verified to be of human origin and negative for interspecies contamination from mouse, rat, Chinese hamster, Golden Syrian hamster, and nonhuman primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
- Cells are negative for mycoplasma contamination.
特徴および利点
The OCUG-1 human gallbladder carcinoma cell line has been used to study hapatobiliary cancer in genome-wide mutation and expression studies.
ターゲットの説明
SCC642 (OCUG-1), the human gallbladder carcinoma cell line, was isolated from the peritoneal effusion of a Japanese male patient with malignant gallbladder carcinoma. Although the primary tumor was diagnosed as a poorly differentiated adenocarcinoma, and the reconstituted tumors in nude mice also exhibited the same histologic characteristics, the OCUG-1 cells were found to abundantly express the Tumor-Associated Antigen 4 (TA-4), which had been identified as a serum marker for cervical squamous cell carcinoma. This led Yamada et al. to propose that OCUG-1 might be a transitional form between adenocarcinoma and squamous cell carcinoma and represented a useful model system for investigating the squamatization processes. Subsequently, one of the major components of TA-4, the Squamous Cell Carcinoma Antigen 1 (SCCA1, also known as SERPINB3, the Serine Protease Inhibitor Clade B Member 3), was shown to induce the squamatization and disease progression in pancreatic cancer by the inhibition of the degradation of the MYC proto-oncogene.
As one of the relatively few available gallbladder cancer cell lines, OCUG-1 has been examined as a representative hapatobiliary cancer in genome-wide mutation and expression studies. In one such study, Scherer et al. noted that the expression profile of the known primary gallbladder tumor markers is not commonly shared by the gallbladder cancer cell lines and suggested that investigators choose their cellular platforms based not only on the tissue origin of the tumors but also on the driver gene expression patterns underlying the specific mechanisms of tumorigenesis.
Source
SCC642 cell line was isolated from the peritoneal effusion of a 43 year old Japanese male patient with malignant gallbladder carcinoma.
References
1. Yamada N, Chung Y, Ohtani H, Ikeda T, Onoda N, Sawada T, Nishiguchi Y, Hasuma T, Sowa M. Establishment and characterization of a new human gallbladder carcinoma cell line (OCUG-1) producing TA-4. Int J Oncol. 1997 Jun;10(6):1251-5.
As one of the relatively few available gallbladder cancer cell lines, OCUG-1 has been examined as a representative hapatobiliary cancer in genome-wide mutation and expression studies. In one such study, Scherer et al. noted that the expression profile of the known primary gallbladder tumor markers is not commonly shared by the gallbladder cancer cell lines and suggested that investigators choose their cellular platforms based not only on the tissue origin of the tumors but also on the driver gene expression patterns underlying the specific mechanisms of tumorigenesis.
Source
SCC642 cell line was isolated from the peritoneal effusion of a 43 year old Japanese male patient with malignant gallbladder carcinoma.
References
1. Yamada N, Chung Y, Ohtani H, Ikeda T, Onoda N, Sawada T, Nishiguchi Y, Hasuma T, Sowa M. Establishment and characterization of a new human gallbladder carcinoma cell line (OCUG-1) producing TA-4. Int J Oncol. 1997 Jun;10(6):1251-5.
保管および安定性
OCUG-1 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages without significantly affecting cell marker expression and function.
その他情報
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@milliporesigma.com.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SCC642:
試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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