MABT213

Anti-SHP-1 Antibody, clone HG213, rabbit monoclonal

clone HG213, from rabbit, unconjugated

• 別名: Tyrosine-protein phosphatase non-receptor type 6, Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: unpurified
• 抗体製品タイプ: primary antibodies
• クローン: HG213, monoclonal
• 化学種の反応性: human
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_002822
• UniProtアクセッション番号: P29350
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PTPN6(5777)

詳細

詳細

Src Homology region 2 domain Phosphatase 1 (SHP-1) is also known as Protein Tyrosine Phosphatase 1C (PTP1C), Protein Tyrosine Phosphatase non-receptor type 6 (PTPN6), and Hematopoietic Cell Phosphatase (HCPH). SHP-1 is a SH2 domain-containing cytosolic tyrosine phosphatase characterized by a catalytic phosphatase domain of approximately 240 amino acids that selectively dephosphorylates tyrosine residues in proteins; the SH2 domains are critical for SHP-1 to bind to ITIM domains in inhibitory immunoreceptors. SHP-1 is highly expressed in hematopoietic tissues and has a negative impact on lymphocyte signaling. SHP-1 is implicated in the control of tyrosine kinase signaling pathways in cellular proliferation, with a potential role in cancer.

免疫原

Full-length glutathione transferase SHP-1 fusion protein, purified from bacteria.

アプリケーション

Research Category
細胞骨格

Research Sub Category
細胞骨格シグナル伝達

Anti-SHP-1 Antibody, clone HG213 detects level of SHP-1 & has been published & validated for use in WB.

品質

Evaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected SHP-1 in 10 µg of Jurkat cell lysate.

ターゲットの説明

~67 kDa observed.
3 isoforms exist with molecular weights between 63 kDa and 68 kDa

物理的形状

Unpurified

Rabbit monoclonal supernatant without sodium azide.

保管および安定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

アナリシスノート

Control
Jurkat cell lysate

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable