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由来生物
mouse
品質水準
抗体製品の状態
purified antibody
抗体製品タイプ
primary antibodies
クローン
ASC-6, monoclonal
化学種の反応性
human
メーカー／製品名
Chemicon®
テクニック
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
アイソタイプ
IgG1κ
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ITGA3(3675)
特異性
Human alpha3 integrin (CD49c)
免疫原
Human squamous cell carcinoma cells (SCC9)
アプリケーション
Research Category
細胞骨格
細胞骨格
Research Sub Category
インテグリン
インテグリン
Anti-Integrin α3 Antibody, clone ASC-6 is an antibody against Integrin α3 for use in FC, IP, IH.
Inhibition of cell attachment: inhibits SCC9 cell adhesion to human and EHS laminin, but not laminin peptide GD-2. Potentiates inhibition of SKOV-3 cell adhesion to EHS laminin by anti-integrin alpha 5 antibody GoH3. Does not inhibit either cell′s adhesion to fibronectin or collagen type IV.
Immunohistochemistry: on acetone-fixed frozen human epithelial tissues including tongue,foreskin and ovary. Not for use on formalin-fixed tissue.
Flow cytometry: stains human squamous cell carcinoma (SCC9), ovarian carcinoma (SKOV-3) and umbilical vein endothelial cells (HUVEC).
Working dilutions must be determined by end user.
Immunohistochemistry: on acetone-fixed frozen human epithelial tissues including tongue,foreskin and ovary. Not for use on formalin-fixed tissue.
Flow cytometry: stains human squamous cell carcinoma (SCC9), ovarian carcinoma (SKOV-3) and umbilical vein endothelial cells (HUVEC).
Working dilutions must be determined by end user.
物理的形状
Format: Purified
Liquid in 0.02M PB pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
保管および安定性
Maintain at 2-8°C in undiluted aliquots for up to 6 months.
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
MAB2057:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Yu-Chen Gu et al.
Blood, 101(3), 877-885 (2002-10-24)
Laminins are alphabetagamma heterotrimeric extracellular proteins that regulate cellular functions by adhesion to integrin and nonintegrin receptors. Laminins containing alpha4 and alpha5 chains are expressed in bone marrow, but their interactions with hematopoietic progenitors are unknown. We studied human bone
Yi I Wu et al.
The Biochemical journal, 407(2), 171-177 (2007-07-26)
The transmembrane collagenase MT1-MMP (membrane-type 1 matrix metalloproteinase), also known as MMP-14, has a critical function both in normal development and in cancer progression, and is subject to extensive controls at the post-translational level which affect proteinase activity. As zymogen
Andrey Makarov et al.
Cell biology international, 37(10), 1080-1088 (2013-05-21)
Glioblastoma is the most common brain cancer. Ephrins and their Eph receptors play important roles in the development of central nervous system and the regulation of cancer cell migration and invasion. In a search for the Eph receptor complexes, we
Michelle B Chen et al.
Cancer research, 76(9), 2513-2524 (2016-03-19)
Tumor integrin β1 (ITGB1) contributes to primary tumor growth and metastasis, but its specific roles in extravasation have not yet been clearly elucidated. In this study, we engineered a three-dimensional microfluidic model of the human microvasculature to recapitulate the environment
Piia Vehviläinen et al.
The Journal of biological chemistry, 278(27), 24705-24713 (2003-04-30)
Of the four latent transforming growth factor (TGF)-beta-binding proteins (LTBPs), LTBP-2 is different in the respect that it does not bind small latent forms of TGF-beta. LTBP-2 is therefore likely to have other roles in the extracellular matrix. LTBP-2 contains
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