ABT187

Anti-TRPM8 Antibody

from rabbit, purified by affinity chromatography

• 別名: Transient receptor potential cation channel subfamily M member 8, Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, Trp-p8, TRPM8
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• 化学種の反応性（ホモロジーによる予測）: baboon (based on 100% sequence homology)
• テクニック: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBIアクセッション番号: NP_076985
• UniProtアクセッション番号: Q7Z2W7
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TRPM8(79054)

詳細

詳細

Transient receptor potential cation channel subfamily M member 8 (TRPM8) is also known as Long transient receptor potential channel 6 (LTrpC-6), and Transient receptor potential p8 (Trp-p8). TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness. TRPM8 is activated by icilin, eucalyptol, menthol, cold and changes to intracellular pH. TRPM8 is expressed in prostate as well as tumors of the prostate, colon, lung, breast and skin. TRPM8 expression in most prostate tumors and the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers.

特異性

Other homologies: Bovine (88% sequence homology), Canine (71% sequence homology), and Mouse and Rat (53% sequence homology).

This antibody recognizes the cytoplasmic domain of TRPM8. This antibody will recognize isoform 1.

免疫原

Epitope: Cytoplasmic domain

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human TRPM8.

アプリケーション

Research Category
細胞骨格

Research Sub Category
接着分子（CAM）

Detect TRPM8 using this rabbit polyclonal antibody, Anti-TRPM8 Antibody validated for use in western blotting & IHC (Paraffin).

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TRPM8 in human prostate cancer and breast cancer cells.

品質

Evaluated by Western Blotting in LNCaP cell lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected TRPM8 in 10 µg of LNCaP cell lysate.

ターゲットの説明

~115 kDa observed

物理的形状

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
LNCaP cell lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable