ABS518
Anti-SLC5A3 Antibody
from rabbit, purified by affinity chromatography
別名:
Sodium/myo-inositol cotransporter, Na(+)/myo-inositol cotransporter, Sodium/myo-inositol transporter 1, SMIT1, Solute carrier family 5 member 3
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About This Item
UNSPSCコード:
12352203
eCl@ss:
32160702
NACRES:
NA.41
価格・在庫情報は確認できません。詳細については、Merckをご覧ください。
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由来生物
rabbit
品質水準
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
精製方法
affinity chromatography
化学種の反応性
human
テクニック
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... SLC5A3(6526)
詳細
SLC5A3, also known as Sodium/myo-inositol cotransporter, Na (+)/myo-inositol cotransporter, Sodium/myo-inositol transporter 1 (SMT1), or Solute carrier family 5 member 3, and encoded by the gene SLC5A3, is an important intracellular transporter and signaling mediator that mediates the intracellular accumulation of myo-inositol. The compound myo-inositol is important for cell signaling both in the cytoplasm and in intracellular organelles. It is required in the plasma membrane and in the cytoplasm for maintaining the synthesis of the second messengers such as Inositol trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol bisphosphate (PIP2). In organelles myo-inositol is a precursor for the synthesis of complex signaling phospholipids and inositolphosphates from IP3 and PIP2 as well. Moreover, SLC5A3 is upregulated by osmotic shock and downregulated by energy depletion and serves as a molecular sensor of cellular stress.
免疫原
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human SLC5A3.
アプリケーション
Detect SLC5A3 using this Anti-SLC5A3 Antibody validated for use in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected SLC5A3 in human prostate tissues.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SLC5A3 in human placenta tissues.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SLC5A3 in human placenta tissues.
品質
Evaluated by Western Blotting in HUVEC cell lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected SLC5A3 in 10 μg of HUVEC cell lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected SLC5A3 in 10 μg of HUVEC cell lysate.
ターゲットの説明
~79 kDa observed
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
ABS518:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Ping Zheng et al.
Cell reports. Medicine, 4(6), 101057-101057 (2023-06-02)
Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased samples of the diverse cell types in the brain. With the advances of multi-omics datasets, a major challenge is to validate and integrate results into a biological understanding of spatial
Heidy Cabrera-Cruz et al.
American journal of physiology. Endocrinology and metabolism, 318(2), E237-E248 (2019-12-25)
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder characterized by hyperandrogenism and ovulatory dysfunction but also obesity and hyperinsulinemia. These characteristics induce an insulin-resistant state in tissues such as the endometrium, affecting its reproductive functions. Myo-inositol (MYO) is an insulin-sensitizing
April R Foster et al.
Aging cell, 19(1), e13058-e13058 (2019-11-27)
Aging is characterized by the deterioration of tissue structure and function. In skin, environmental factors, for example, ultraviolet radiation (UVR), can accelerate the effects of aging such as decline in barrier function and subsequent loss of hydration. Water homeostasis is
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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