ABE1330

Anti-FUSE-binding protein 1 Antibody

from rabbit, purified by affinity chromatography

• 別名: Far upstream element-binding protein 1, FBP, FUSE-binding protein 1, DNA helicase V, hDH V
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 交差性: human
• 交差性（ホモロジーによる予測）: feline (based on 100% sequence homology), primate (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology), horse (based on 100% sequence homology)
• テクニック: immunocytochemistry: suitable; western blot: suitable
• NCBIアクセッション番号: NP_003893
• UniProtアクセッション番号: Q96AE4
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FUBP1(8880)

詳細

詳細

FUSE-binding protein 1, also known as Far upstream element-binding protein 1 FBP, FUSE-binding protein 1, DNA helicase V, hDH V, and encoded by the gene name FUBP1, regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. FUSE may act both as activator and repressor of transcription. There are three known FUSE binding proteins (FBP1, FBP2, and FBP3). All three belong to an ancient family of single-stranded DNA binding proteins. These proteins are required for regulation of the c-myc proto-oncogene and have been shown to bind to an A/T-rich element (far-ustream element) located 1.7 kb upstream of the c-myc P2 promoter. Although their primary sequences are closely related, the FBP, FBP2, and FBP3 genes are located on different chromosomes in both mice and humans. FUSE binding proteins are believed to be multifunctional. Besides regulating the transcription of c-myc (and quite likely other targets), the FBP family has been shown to bind a variety of RNAs in vitro.

免疫原

Epitope: Near N-terminal

KLH-conjugated linear peptide corresponding to human FUSE-binding protein 1 near the N-terminal.

アプリケーション

Research Category
エピジェネティクス及び核内機能分子

Research Sub Category
核受容体

Immunocytochemistry Analysis: 2.0 µg/mL from a representative lot detected FUSE-binding protein 1 in HeLa and A431 cells.

This Anti-FUSE-binding protein 1 | ABE1330 antibody is validated for use in WB, IC for the detection of FUSE-binding protein 1 | ABE1330.

品質

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected FUSE-binding protein 1 in 10 µg of HeLa cell lysate.

ターゲットの説明

~76 kDa observed. Uncharacterized band(s) may appear in some lysates.

物理的形状

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable