主要文書

すべての文書を表示

スキップする

692000

ZM 336372

Name: ZM 336372
Brand: MM

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC₅₀ = 70 nM).

別名:

ZM 336372, N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide

ログインで組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

あなたへ/カタログ番号	在庫状況	単価

この商品について

実験式（ヒル表記法）:

C₂₃H₂₃N₃O₃

CAS番号:

208260-29-1

分子量:

389.45

UNSPSC Code:

12352117

NACRES:

NA.77

MDL number:

MFCD02683971

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

この製品は、Merck Milliporeウェブサイトでのみ注文できます。

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

特性

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 200 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

N(C)(C)c1cc(ccc1)C(=O)Nc2cc(c(cc2)C)NC(=O)c3ccc(cc3)O

InChI

1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)

InChI key

PYEFPDQFAZNXLI-UHFFFAOYSA-N

詳細

General description

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC₅₀ = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC₅₀ = 2 µM) and SAPK2b/p38β2 (IC₅₀ = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Protein kinase c-Raf

Product competes with ATP.

Reversible: yes

Target IC₅₀: 70 nM against protein kinase c-Raf

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

Other Notes

Hall-Jackson, C.A., et al. 1999. Chem. Biol.6, 559.

Legal Information

Sold under license of PCT Application W098/22,103.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

類似品目との比較

比較内容をすべて表示

相違点を表示

1 of 1

当該品目	506163	420101	361553
Sigma-Aldrich 692000 ZM 336372	Sigma-Aldrich 506163 p38 MAP Kinase Inhibitor VIII	Sigma-Aldrich 420101 JAK3 Inhibitor I	Sigma-Aldrich 361553 GSK-3β Inhibitor XI
form solid	form solid	form solid	form solid
assay ≥95% (HPLC)	assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 200 mg/mL	solubility ethanol: 15 mg/mL, DMSO: 50 mg/mL	solubility DMSO: 50 mg/mL	solubility DMSO: 5 mg/mL

Still not finding the right product?

Explore all of our products under ZM 336372

pictograms

GHS07

signalword

Warning

hcodes

H317,H413

pcodes

P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313

Hazard Classifications

Aquatic Chronic 4 - Skin Sens. 1B

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c