567806

Src Kinase Inhibitor II

The Src Kinase Inhibitor II, also referenced under CAS 459848-35-2, controls the biological activity of Src Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Src Kinase Inhibitor II
• 実験式（ヒル表記法）: C₂₂H₂₀N₄O₃S
• CAS番号: 459848-35-2
• 分子量: 420.48
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: pale orange
• 溶解性: DMSO: 20 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A potent, selective, reversible, and ATP-competitive inhibitor of Src family tyrosine kinases (IC₅₀ = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR tyrosine kinase even at concentrations as high as 50 µM.

A substituted triazoloquinoline-1-thione compound that acts as a potent, ATP-competitive, reversible and selective inhibitor of Src family tyrosine kinases (IC₅₀ = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR even at concentrations as high as 50 µM.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
human recombinant Csk

Product competes with ATP.

Reversible: yes

Target IC₅₀: 1.2 µM for human recombinant Csk

包装

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Kilimnik, A., et al. 2003. Cell. Mol. Biol. Lett.8, 588.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable