557353

RORγ Inverse Agonist, SR2211

The RORγ Inverse Agonist, SR2211 controls the biological activity of RORγ.

• 別名: RORγ Inverse Agonist, SR2211, 1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4′-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1′-biphenyl]-4-yl)propan-2-ol, SR-2211, SR 2211
• 実験式（ヒル表記法）: C₂₆H₂₄F₇N₃O
• CAS番号: 1359164-11-6
• 分子量: 527.48
• MDL番号: MFCD25563263
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥99% (HPLC)
• フォーム: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 50 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: FC1=CC(C(O)(C(F)(F)F)C(F)(F)F)=CC=C1C2=CC=C(CN3CCN(CC4=CC=NC=C4)CC3)C=C2

詳細

詳細

A cell-permeable, piperazine containing biphenyl compound that binds directly to retinoic acid receptor related orphan receptor γ (RORg) and acts as a highly selective and inverse agonist (K_i = 105 nM; IC₅₀ ~ 320 nM). Reported to block the transcriptional activity of RORg and suppress the synthesis of IL-17 in EL-4 murine lymphoma cell line. Exhibits only a minimal effect on RORa and LXRa activity.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Kumar, N., et al. 2012. ACS Chem. Biol.7, 672.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable