553018-M

RAF Kinase Inhibitor VII

• 別名: RAF Kinase Inhibitor VII, 1-(4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
• 実験式（ヒル表記法）: C₂₁H₁₅ClF₃N₅O₃S
• CAS番号: 884339-61-1
• 分子量: 509.89
• UNSPSCコード: 12352200

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• 形状: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: caramel
• 溶解性: DMSO: 50 mg/mL
• 保管温度: −20°C

詳細

詳細

A cell-permeable imidazopyridinyl-urea compound that acts as a potent inhibitor against B-Raf^V600E activity (IC₅₀ = 1 nM) by targeting its ATP-binding pocket and the adjacent lipophilic allosteric site accessible only when the enzyme is in its inactive DFG-out conformation. Reported to effectively inhibit Raf^V600E-dependent ERK phosphorylation (IC₅₀ = 610 nM) and growth of human melanoma WM266.4 cells (GI₅₀ = 470 nM).

警告

Toxicity: Regulatory Review (Z)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Menard, D., et al. 2009. J. Med. Chem.52, 3881.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable