538916

16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem

A cell-permeable and orally available synthetic PGE2.

• 別名: 16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem
• 実験式（ヒル表記法）: C₂₂H₃₆O₅
• CAS番号: 39746-25-3
• 分子量: 380.52
• MDL番号: MFCD00151141
• UNSPSCコード: 12352200

特性

• アッセイ: ≥95% (HPLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 溶解性: DMSO: 100 mg/mL; ethanol: 100 mg/mL; PBS, pH 7.2: 5 mg/mL
• 輸送温度: wet ice
• 保管温度: −70°C
• InChI: 1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6+,13-12+/t16-,17?,19-,20+/m0/s1
• InChI Key: QAOBBBBDJSWHMU-BKSAQPBESA-N

詳細

詳細

A cell-permeable and orally available synthetic PGE2.

A cell-permeable and orally available synthetic PGE₂ (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE₂ as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

A cell-permeable and orally available synthetic PGE₂ (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE₂ as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

警告

Toxicity: Flammable (J)

物理的形状

Supplied as a solution in methylacetate (1 mg/100 µL)

調製ノート

Gently blow away methylacetate under a stream of N2 and solubilize in either DMSO or EtOH purged with an inert gas.

再構成

Following reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Goessling, W., et al. 2009. Cell136, 1136.
Fitzgerald, J., et al. 2000. Endocrinology141, 291.
Coleman, R.A., et al. 1994. Pharmacol. Rev.46, 205.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS07
• シグナルワード: Danger
• 危険有害性情報: H225,H319,H336
• 注意書き: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• ターゲットの組織: Central nervous system
• 補足的ハザード: EUH066
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 3.2 °F - closed cup
• 引火点(℃): -16 °C - closed cup